Volume 58, Issue 6, Pages 2492-2501 (December 2000) Volumetric determination of progression in autosomal dominant polycystic kidney disease by computed tomography  Cori Sise, Masatomo Kusaka, Louis H. Wetzel, Franz Winklhofer, Benjamin D. Cowley, Larry T. Cook, Michael Gordon, Jared J. Grantham  Kidney International  Volume 58, Issue 6, Pages 2492-2501 (December 2000) DOI: 10.1046/j.1523-1755.2000.00433.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Sequential contrast-enhanced computed tomography (CT) scans obtained in patient 5. Cross-section slices were obtained at approximately the same locations within individual kidneys. These scans illustrate the accumulation of contrast within the parenchyma to levels exceeding that of liver, skeletal muscle, and intrarenal cysts. Note the enlargement of the large spherical cyst on the anterior surface of the right kidney between 1985 and 1988. In 1992, an operation was performed at the University of Oregon Health Sciences Center on the right kidney to remove cysts and decrease the overall size. Cyst decompression in the right kidney was evident two years later (Right, 1994). In contrast, the unoperated left kidney enlarged progressively from 1985 to 1994. Kidney International 2000 58, 2492-2501DOI: (10.1046/j.1523-1755.2000.00433.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Relationship between change in total kidney volume (Vt) of right and left kidneys in 10 ADPKD patients studied on two separate occasions. Regression line is as follows: (left kidney, mL) = 4.5 mL + 1.03 × (right kidney, mL); r2 = 0.77, P < 0.01. Kidney International 2000 58, 2492-2501DOI: (10.1046/j.1523-1755.2000.00433.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 Relationship between age and kidney volume, Vt, for individual kidneys studied on two occasions. Symbols are: (•) left; (○) right. Kidney International 2000 58, 2492-2501DOI: (10.1046/j.1523-1755.2000.00433.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 4 Sequential determinations of volume in individual cysts (discussed in the main body of the text). Kidney International 2000 58, 2492-2501DOI: (10.1046/j.1523-1755.2000.00433.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 5 Relationship between the initial kidney volume (A), rate of kidney volume increase and initial fractional cyst volume (B), and functional outcome (C). Kidney International 2000 58, 2492-2501DOI: (10.1046/j.1523-1755.2000.00433.x) Copyright © 2000 International Society of Nephrology Terms and Conditions