Erick Forno, MD, MPH, Yueh-Ying Han, PhD, Radhika H

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Presentation transcript:

Insulin resistance, metabolic syndrome, and lung function in US adolescents with and without asthma Erick Forno, MD, MPH, Yueh-Ying Han, PhD, Radhika H. Muzumdar, MD, Juan C. Celedón, MD, DrPH Journal of Allergy and Clinical Immunology Volume 136, Issue 2, Pages 304-311.e8 (August 2015) DOI: 10.1016/j.jaci.2015.01.010 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 BMI z score and lung function by insulin resistance status (HOMA-IR value of <3.0 vs >3.0). A, Predicted values for FEV1. B, FEV1/FVC ratio. All models were adjusted for age, sex, race/ethnicity, asthma status, health insurance coverage, family history of asthma, environmental tobacco smoke exposure, fasting hours, and CRP levels. Interaction P for FEV1 = .0006; interaction P for FEV1/FVC ratio = .02. Journal of Allergy and Clinical Immunology 2015 136, 304-311.e8DOI: (10.1016/j.jaci.2015.01.010) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Predicted FEV1/FVC ratio by asthma and MS status. All models were adjusted for age, sex, race/ethnicity, health insurance coverage, family history of asthma, environmental tobacco smoke exposure, fasting hours, CRP levels, and z scores for each adiposity indicator (A, BMI; B, PBF; C, WC; D, WHtR). No asthma and no MS, n = 496; MS only, n = 58; asthma only, n = 23; and MS and asthma, n = 7. *P < .05 compared with the control group (no asthma and no MS). Journal of Allergy and Clinical Immunology 2015 136, 304-311.e8DOI: (10.1016/j.jaci.2015.01.010) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Derivation of the study sample from NHANES 2007-2008 and 2009-2010. Journal of Allergy and Clinical Immunology 2015 136, 304-311.e8DOI: (10.1016/j.jaci.2015.01.010) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Predicted FEV1 by asthma and MS status. All models were adjusted for age, sex, race/ethnicity, health insurance coverage, family history of asthma, environmental tobacco smoke exposure, fasting hours, CRP levels, and z scores for each adiposity indicator (A, BMI; B, PBF; C, WC; D, WHtR). No asthma and no MS, n = 496; MS only, n = 58; asthma only, n = 23; and MS and asthma, n = 7. *P < .05 compared with the control group (no asthma and no MS). Journal of Allergy and Clinical Immunology 2015 136, 304-311.e8DOI: (10.1016/j.jaci.2015.01.010) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions