Compliments of Factor H: What’s in it for AMD?

Slides:

Advertisements

Similar presentations

Bacterial Entry to the Splenic White Pulp Initiates Antigen Presentation to CD8+ T Cells Taiki Aoshi, Bernd H. Zinselmeyer, Vjollca Konjufca, Jennifer.

Advertisements

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.

The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection Myoungjoo V. Kim, Weiming Ouyang, Will Liao, Michael Q. Zhang,

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation Timotheus Y.F. Halim, Ramona.

Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells Julien Seneschal, Rachael A. Clark,

Anti-Third Party CD8+ CTLs as Potent Veto Cells S Reich-Zeliger, Y Zhao, R Krauthgamer, E Bachar-Lustig, Y Reisner Immunity Volume 13, Issue 4, Pages

Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus Bram Slütter, Lecia L. Pewe, Susan M. Kaech,

The Roles of Fas/APO-1 (CD95) and TNF in Antigen-Induced Programmed Cell Death in T Cell Receptor Transgenic Mice Huey-Kang Sytwu, Roland S Liblau, Hugh.

Joseph P. Kolb, Jennifer Martinez Immunity

CD5: A New Partner for IL-6

An Activation Marker Finds a Function

The Leptin Connection: Regulatory T Cells and Autoimmunity

PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria

Memory: The Incomplete Unhappening of Differentiation

Stop Press: Eosinophils Drafted to Join the Th17 Team

Volume 29, Issue 5, Pages (November 2008)

Some DCs Are “B”etter Immunity

Notch: Filling a Hole in T Helper 2 Cell Differentiation

Loss of CD47 Makes Dendritic Cells See Red

Nicholas van Bruggen, Wenjun Ouyang Immunity

Thomas A. Waldmann, Sigrid Dubois, Yutaka Tagaya Immunity

Chronic Infections Capture Little Attention of the Masses

JAK's SOCS: A Mechanism of Inhibition

miR-155-SOCS1 as a Functional Axis: Satisfying the Burden of Proof

Checks and Balances: IL-23 in the Intestine

POPsicle for Fever! Cooling Down the Inflammasome

Unraveling the Pros and Cons of Interferon-γ Gene Regulation

The Case of the Disappearing Drug Target

PU.1 Takes Control of the Dendritic Cell Lineage

Mushrooming Insights into Skin Dendritic Cell Physiology

A Local Role for CD103+ Dendritic Cells in Atherosclerosis

Intracellular Pathogens and CD8+ Dendritic Cells: Dangerous Liaisons

IL-2: Change Structure … Change Function

Arming Treg Cells at the Inflammatory Site

A Rogue Foxp3 Mutant Undermines Treg Cell Function

MicroRNAs in Tfh Cells: Micromanaging Inflammaging

Amyloid Cascade into Clarity

Volume 26, Issue 2, Pages (February 2018)

Volume 26, Issue 3, Pages (March 2007)

Chronic Infections Capture Little Attention of the Masses

BTLA+ Dendritic Cells: The Regulatory T Cell Force Awakens

Volume 152, Issue 1, (January 2013)

Loss of CD47 Makes Dendritic Cells See Red

An IL-1β-Dependent Switch in Innate Mucosal Immunity?

Volume 130, Issue 6, (September 2007)

T Cells Are Smad’ly in Love with Galectin-9

Taia T. Wang, Jeffrey V. Ravetch Immunity

T Cell Cosignaling Molecules in Transplantation

PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria

Volume 143, Issue 6, (December 2010)

Volume 17, Issue 2, Pages (February 1950)

HIV and HLA Class I: An Evolving Relationship

Volume 30, Issue 2, Pages (February 2009)

T-bet Runs INTERFERence

One Bug or Another: Promiscuous T Cells Form Lifelong Memory

Volume 82, Issue 9, Pages (November 2012)

Volume 70, Issue 3, Pages (August 2006)

Volume 163, Issue 4, (November 2015)

Volume 4, Issue 1, Pages 2-3 (February 2006)

Regulatory T Cells and Inflammation: Better Late Than Never

Volume 163, Issue 2, (October 2015)

Some DCs Are “B”etter Immunity

Volume 134, Issue 6, (September 2008)

Nora A. Barrett, K. Frank Austen Immunity

PTENtiating CFTR for Antimicrobial Immunity

Marking Emerging β- and γδ-Selected T Cells

In This Issue Cell Volume 145, Issue 3, (April 2011)

Volume 148, Issue 1, (January 2012)

IL-9 by INFERence Immunity

Presentation transcript:

Compliments of Factor H: What’s in it for AMD? Mary J. Mattapallil, Rachel R. Caspi Immunity Volume 46, Issue 2, Pages 167-169 (February 2017) DOI: 10.1016/j.immuni.2017.02.008 Copyright © 2017 Terms and Conditions

Figure 1 CFH-CD11b Complex Binds to CD47 on Microglial Cells in the Retina, Competing with Binding of TSP1 The consequence of this interaction is inhibition of CD47 driven clearance of mononuclear phagocytes, whose role is removal of physiological waste products, promoting inflammation characteristic of AMD. Immunity 2017 46, 167-169DOI: (10.1016/j.immuni.2017.02.008) Copyright © 2017 Terms and Conditions