Impaired hemidesmosome formation in clint1 mutants.

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Impaired hemidesmosome formation in clint1 mutants. Impaired hemidesmosome formation in clint1 mutants. Transmission electron micrographs of transverse sections of wild-type (A-D) and clint1 mutant (A′-D′,E,F) zebrafish embryos staged at 4 dpf. The dashed boxed regions in A and A′ are magnified in B and B′, respectively. The solid boxed region in A is magnified in C. Arrowheads label hemidesmosomes (B), desmosomes (C,C′), tight junctions (D,D′), cellular fragmentation (A′,F) and condensed nuclei (E). Asterisks highlight absence of hemidesmosomes (B′) and detachment of epidermal cells (C′). N, nucleus; BL, basal lamina. Scale bars: 1μ m. M. Ernest Dodd et al. Development 2009;136:2591-2600 © 2009.