Volume 123, Issue 1, Pages 41-49 (July 2002) Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritis  Lynne E. Vinall, Marie King, Marco Novelli, Carole A. Green, Geoff Daniels, John Hilkens, Martin Sarner, Dallas M. Swallow  Gastroenterology  Volume 123, Issue 1, Pages 41-49 (July 2002) DOI: 10.1053/gast.2002.34157 Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 1 MUC1 TR sequence showing 2 complete repeats and the positions of the TR epitopes detected by the antibodies LICRLonM8 and C595. Potential glycosylation sites are underlined. Gastroenterology 2002 123, 41-49DOI: (10.1053/gast.2002.34157) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 2 Examples of LICRLonM8 staining of antral biopsy specimens. Strong apical staining of surface epithelium, superficial glands, and mucus (biopsy specimen from a patient with normal histology). Perinuclear staining in the surface epithelium (biopsy specimen from a patient with H. pylori gastritis). Gastroenterology 2002 123, 41-49DOI: (10.1053/gast.2002.34157) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 3 Example of the very different pattern of staining of the TR antibody C595 and the cytoplasmic tail antibody F33. A and C are from an antral biopsy specimen from a patient with normal mucosa, and B and D show staining in a patient with normal H. pylori gastritis. A and B are stained with C595 and C and D with F33. Gastroenterology 2002 123, 41-49DOI: (10.1053/gast.2002.34157) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 4 MUC1 allele length distribution. Histogram showing the distribution of allele lengths for each of the 3 groups (the data are shown as numbers of alleles; note that each individual has 2 alleles). Distribution of allele lengths, expressed as percentages, of the normal and H. pylori gastritis categories are compared with the larger set of Northern European individuals (n = 54 alleles, 27 people with normal histology; 46 alleles, 23 people with H. pylori gastritis; 446 alleles, 223 people, all other Northern European samples) Gastroenterology 2002 123, 41-49DOI: (10.1053/gast.2002.34157) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 5 Comparison of MUC1 short and long alleles. Histogram showing the genotype of individuals in each group after recoding according to allele size. L, alleles 5.0 kilobases and longer; S, alleles shorter than 5.0 kilobases. Total number of alleles L and S in each of the 3 groups. Gastroenterology 2002 123, 41-49DOI: (10.1053/gast.2002.34157) Copyright © 2002 American Gastroenterological Association Terms and Conditions