The effects of antihistamines on cognition and performance

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Presentation transcript:

The effects of antihistamines on cognition and performance Gary G Kay, PhD Journal of Allergy and Clinical Immunology Volume 105, Issue 6, Pages S622-S627 (June 2000) DOI: 10.1067/mai.2000.106153

Fig. 1 . Factual knowledge scores (mean ± SE) in children with no allergy (NOR ) versus children with allergy who were treated with the nonsedating antihistamine loratadine (LOR ), placebo (PLA ), or the sedating antihistamine diphenhydramine (DIP ). (Modified with permission from Vuurman EFPM, van Veggel LMA, Uiterwijk MMC, Leutner D, O’Hanlon JF. Seasonal allergic rhinitis and antihistamine effects on children’s learning. Ann Allergy 1993;71:121-6. Copyright ACAAI.) Journal of Allergy and Clinical Immunology 2000 105, S622-S627DOI: (10.1067/mai.2000.106153)

Fig. 2 . Conceptual knowledge scores (mean ± SE) in children with no allergy (NOR ) versus children with allergy who were treated with the nonsedating antihistamine loratadine (LOR ), placebo (PLA ), or the sedating antihistamine diphenhydramine (DIP ). (Modified with permission from Vuurman EFPM, van Veggel LMA, Uiterwijk MMC, Leutner D, O’Hanlon JF. Seasonal allergic rhinitis and antihistamine effects on children’s learning. Ann Allergy 1993;71:121-6. Copyright ACAAI.) Journal of Allergy and Clinical Immunology 2000 105, S622-S627DOI: (10.1067/mai.2000.106153)

Fig. 3 . Knowledge application scores (mean ± SE) in children with no allergy (NOR ) versus children with allergy who were treated with the nonsedating antihistamine loratadine (LOR ), placebo (PLA ), or the sedating antihistamine diphenhydramine (DIP ). (Modified with permission from Vuurman EFPM, van Veggel LMA, Uiterwijk MMC, Leutner D, O’Hanlon JF. Seasonal allergic rhinitis and antihistamine effects on children’s learning. Ann Allergy 1993;71:121-6. Copyright ACAAI.) Journal of Allergy and Clinical Immunology 2000 105, S622-S627DOI: (10.1067/mai.2000.106153)

Fig. 4 . Mean change from baseline in visual analog scale (VAS ) ratings on day 1 for subjects who were treated with diphenhydramine, loratadine, and placebo. P < .001, loratadine versus diphenhydramine; P < .001, placebo versus diphenhydramine. (Adapted from Kay GG, Berman B, Mockoviak SH, Morris CE, Reeves D, Starbuck V, et al. Initial and steady-state effects of diphenhydramine and loratadine on sedation, cognition, mood, and psychomotor performance. Arch Intern Med 1997;157:2350-6. Copyright 1997, American Medical Association.) Journal of Allergy and Clinical Immunology 2000 105, S622-S627DOI: (10.1067/mai.2000.106153)