Figure Comparison of LC activation in diabetic small fiber neuropathy and normal control(A) PGP9.5 immunostaining shows decreased density of epidermal.

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Figure Comparison of LC activation in diabetic small fiber neuropathy and normal control(A) PGP9.5 immunostaining shows decreased density of epidermal nerve fibers (ENF, arrow) and robust Langerhans cells (LC) staining (arrowheads). Comparison of LC activation in diabetic small fiber neuropathy and normal control(A) PGP9.5 immunostaining shows decreased density of epidermal nerve fibers (ENF, arrow) and robust Langerhans cells (LC) staining (arrowheads). (B) PGP9.5 immunostaining in a 75-year-old man, normal control (distal leg 10.2 ENF/mm, 95% confidence interval [CI] 9.11, 11.4; mid-thigh 9.9 ENF/mm, 95% CI 8.87, 11.05). (C) LC are identified by their positivity to langerin (CD-207). (D) LC staining positive (arrowheads) with S-100. Ezequiel Agustin Piccione et al. Neurol Neuroimmunol Neuroinflamm 2014;1:e42 © 2014 American Academy of Neurology