SGC activity in isolated aortic smooth muscle cells from control (□) and diabetic (STZ) (■) rats was determined under basal conditions and after in vitro.

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sGC activity in isolated aortic smooth muscle cells from control (□) and diabetic (STZ) (■) rats was determined under basal conditions and after in vitro stimulation with HMR1766 and/or the NO donor SNP (A). sGC activity in isolated aortic smooth muscle cells from control (□) and diabetic (STZ) (■) rats was determined under basal conditions and after in vitro stimulation with HMR1766 and/or the NO donor SNP (A). Vasorelaxation induced by HMR1766 was determined in aortic rings from control and diabetic rats (B). C: Concentration-response curves for sGC-independent cGMP-mediated vasorelaxation elicited by cumulative application of 8-bromo-cGMP in isolated aortic rings from control and diabetic rats (STZ) administered either placebo or HMR1766. Data are representative of n = 6 experiments. *P < 0.05 vs. control. Andreas Schäfer et al. Diabetes 2010;59:2001-2009 ©2010 by American Diabetes Association