Elevated plasma F2-isoprostanes in patients on long-term hemodialysis

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Presentation transcript:

Elevated plasma F2-isoprostanes in patients on long-term hemodialysis Garry J. Handelman, Mary F. Walter, Rohini Adhikarla, Jonathan Gross, Gerard E. Dallal, Nathan W. Levin, Jeffrey B. Blumberg Kidney International Volume 59, Issue 5, Pages 1960-1966 (May 2001) DOI: 10.1046/j.1523-1755.2001.0590051960.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 Pathway for enzymatic synthesis of prostaglandin F2α and for free-radical initiated synthesis of F2-isoprostanes. Kidney International 2001 59, 1960-1966DOI: (10.1046/j.1523-1755.2001.0590051960.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 Levels of esterified F2-isoprostanes in end-stage renal disease (ESRD) patients and controls. The difference is significant (P < 0.001). Kidney International 2001 59, 1960-1966DOI: (10.1046/j.1523-1755.2001.0590051960.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 3 Levels of C-reactive protein (CRP) in ESRD patients and controls. The difference is significant (P < 0.02). Kidney International 2001 59, 1960-1966DOI: (10.1046/j.1523-1755.2001.0590051960.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 4 Plasma CRP and F2-isoprostanes in hemodialysis patients, plotted on logarithmic axes for each variable. Kidney International 2001 59, 1960-1966DOI: (10.1046/j.1523-1755.2001.0590051960.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 5 Effects of a single dialysis session on plasma esterified F2-isoprostanes in 10 ESRD patients. F2-isoprostanes in plasma from each patient were measured before and after the HD session. Kidney International 2001 59, 1960-1966DOI: (10.1046/j.1523-1755.2001.0590051960.x) Copyright © 2001 International Society of Nephrology Terms and Conditions