Volume 11, Issue 2, Pages (August 2018)

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Volume 11, Issue 2, Pages 485-496 (August 2018) Recent Trends in Research with Human Pluripotent Stem Cells: Impact of Research and Use of Cell Lines in Experimental Research and Clinical Trials Anke Guhr, Sabine Kobold, Stefanie Seltmann, Andrea E.M. Seiler Wulczyn, Andreas Kurtz, Peter Löser Stem Cell Reports Volume 11, Issue 2, Pages 485-496 (August 2018) DOI: 10.1016/j.stemcr.2018.06.012 Copyright © 2018 The Authors Terms and Conditions

Figure 1 Worldwide Research in Human Pluripotent Stem Cells (A) Number of original research papers published from 2014 to 2016. Included are all studies in which experimental use of hESCs (left) or/and hiPSCs (right) is reported. (B) Number of research papers published on experimental use of hESCs (left) or/and hiPSCs (right) in the 3-year periods indicated. The number of papers in which both hESCs and hiPSCs were used in the same study is shown in lighter gray. Mere gold standard usage of hESCs is indicated by gray-white striped lines. Stem Cell Reports 2018 11, 485-496DOI: (10.1016/j.stemcr.2018.06.012) Copyright © 2018 The Authors Terms and Conditions

Figure 2 Allocation of hPSC Research to Specific Countries Share (percentage) of papers from a given country in relation to the total number of hESC research papers (A) and hiPSC research papers (B) for the indicated periods. Only results for countries with more than 50 or 30 original publications in the hESC or hiPSC field, respectively, were included. The numbers to the right of the upper bars relate to the total 9-year period (2008–2016). Stem Cell Reports 2018 11, 485-496DOI: (10.1016/j.stemcr.2018.06.012) Copyright © 2018 The Authors Terms and Conditions

Figure 3 Derivation of New hESC Lines (2008–2016) (A) Number of hESC lines that were reported for the first time in original research papers during the time periods indicated. (B) Percentage of disease-specific (light blue) and clinical-grade (dark blue) hESC lines in total new cell lines reported in original research papers during the time periods indicated. Stem Cell Reports 2018 11, 485-496DOI: (10.1016/j.stemcr.2018.06.012) Copyright © 2018 The Authors Terms and Conditions