Antibodies against malondialdehyde-acetaldehyde adducts can help identify patients with abdominal aortic aneurysm Jeffrey S. Carson, MD, Wanfen Xiong,

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Presentation transcript:

Antibodies against malondialdehyde-acetaldehyde adducts can help identify patients with abdominal aortic aneurysm Jeffrey S. Carson, MD, Wanfen Xiong, MD, PhD, Matthew Dale, BS, Fang Yu, PhD, Michael J. Duryee, MS, Daniel R. Anderson, MD, PhD, Geoffrey M. Thiele, PhD, B. Timothy Baxter, MD Journal of Vascular Surgery Volume 63, Issue 2, Pages 477-485 (February 2016) DOI: 10.1016/j.jvs.2014.08.117 Copyright © 2016 Terms and Conditions

Fig 1 Levels of anti-malondialdehyde-acetaldehyde (MAA) adduct antibodies in human plasma. Concentrations of antibody isotypes were determined from human plasma by competitive enzyme-linked immunosorbent assay with goat immunoglobulin G (IgG) to anti-MAA adduct immunoglobulins G, A, and M (IgG, IgA, and IgM). Data presented are reported as group means ± standard error of the mean of log transformed data. *P < .05 for IgG repaired abdominal aortic aneurysm (AAA) vs unrepaired and control. †P < .05 for IgA repaired AAA vs control. ‡P < .05 for IgM unrepaired AAA and repaired AAA vs control. Journal of Vascular Surgery 2016 63, 477-485DOI: (10.1016/j.jvs.2014.08.117) Copyright © 2016 Terms and Conditions

Fig 2 Top panel, Change in aortic diameter of CaCl2-treated and sham mice. Mouse aortas were treated with 0.25 mM CaCl2 in the treatment group or 0.9% NaCl in the sham group. Aortic diameter was measured at 0 (pre-treatment) and 6 weeks (post-treatment). The difference between the final aortic diameter and the initial diameter was divided by the initial aortic diameter to determine the percentage change in aortic size. Data presented are reported as group means ± standard error of the mean. *P < .05. Lower panel, Light microscopy of mouse aortas stained with Verhoeff–van Gieson at 40× magnification demonstrating normal elastin strands in control NaCl-treated aorta (A) and elastin strand breaks (arrow) in CaCl2-treated aorta (B). Journal of Vascular Surgery 2016 63, 477-485DOI: (10.1016/j.jvs.2014.08.117) Copyright © 2016 Terms and Conditions

Fig 3 Concentrations (ng/ml) of immunoglobulin G (IgG, A) and immunoglobulin M (IgM, B) shown at three perioperative time points. Data presented are mean of log transformed concentrations ± standard error of the mean. *P < .05. Samples for the 0-week time point were obtained before laparotomy and abdominal aortic aneurysm (AAA) induction. Journal of Vascular Surgery 2016 63, 477-485DOI: (10.1016/j.jvs.2014.08.117) Copyright © 2016 Terms and Conditions