Clinical consequences of defects in B-cell development

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Presentation transcript:

Clinical consequences of defects in B-cell development Andre M. Vale, PhD, Harry W. Schroeder, MD, PhD Journal of Allergy and Clinical Immunology Volume 125, Issue 4, Pages 778-787 (April 2010) DOI: 10.1016/j.jaci.2010.02.018 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 B-cell development illustrated as a linear progression through developmental checkpoints. Proper assembly of the B-cell antigen receptor complex is required. The expression pattern of key surface molecules during this process is marked by bars. Also shown are the developmental checkpoints at which loss of function (Δ) of selected transcription factors can influence B-cell development. Journal of Allergy and Clinical Immunology 2010 125, 778-787DOI: (10.1016/j.jaci.2010.02.018) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Schematic morphology of the spleen (A) and the GC reaction (B). The white pulp consists of a central artery surrounded by the periarterial lymphatic sheath (PALS) or T cell zone, the marginal zone, and the follicles. Antigen-specific B and T cells interact at the border of the follicle. The B cells differentiate into centroblasts and undergo clonal expansion in the GC dark zone. Journal of Allergy and Clinical Immunology 2010 125, 778-787DOI: (10.1016/j.jaci.2010.02.018) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions