Radiation dose mapping and anastomotic complications after trimodality therapy for esophageal cancers Andrew Bang, Joel A. Broomfield, Jessica Chan,

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Radiation dose mapping and anastomotic complications after trimodality therapy for esophageal cancers Andrew Bang, Joel A. Broomfield, Jessica Chan, Najlaa Alyamani, Agnes Crnic, Sebastien Gilbert, Jason R. Pantarotto Clinical and Translational Radiation Oncology Volume 15, Pages 76-82 (February 2019) DOI: 10.1016/j.ctro.2018.12.005 Copyright © 2019 The Authors Terms and Conditions

Fig. 1 Three dimensional representation of the reconstructed structures used for dose calculation. The midline contours represent a slice of the esophagus ranging from −2.7 cm to 6.3 cm relative to the top of the azygous vein (0.0 cm). The origin slice is represented by the white asterix. The stomach is subdivided into 4 groups: superior medial, superior lateral, middle and inferior. Clinical and Translational Radiation Oncology 2019 15, 76-82DOI: (10.1016/j.ctro.2018.12.005) Copyright © 2019 The Authors Terms and Conditions

Fig. 2a Overall Survival (OS). Kaplan meier survival curve of patients receiving trimodality therapy. The median OS was 34 months (95% CI: 31–53 months) with a 3y-OS and 5y-OS of 53% and 30% respectively. Clinical and Translational Radiation Oncology 2019 15, 76-82DOI: (10.1016/j.ctro.2018.12.005) Copyright © 2019 The Authors Terms and Conditions

Fig. 2b Disease Free Survival (DFS). Kaplan meier survival curve of patients receiving trimodality therapy. The median DFS was 23 months (95% CI: 15–30 months) with a 3y-DFS and 5y-DFS of 31% and 14% respectively. Clinical and Translational Radiation Oncology 2019 15, 76-82DOI: (10.1016/j.ctro.2018.12.005) Copyright © 2019 The Authors Terms and Conditions

Fig. 3 Mean dose of the esophagus in patients with and without anastomotic complications. Mean dose received by the esophagus at distances above and below the level of the azygous vein. Distances less than 0 cm are below, while distances greater than 0 cm are above. The standard errors are represented. Abbreviations: AC – Anastomotic complications; Gy – Gray; cm – Centimeter *Statistically significant difference (p < 0.05). Clinical and Translational Radiation Oncology 2019 15, 76-82DOI: (10.1016/j.ctro.2018.12.005) Copyright © 2019 The Authors Terms and Conditions