Immune cell recruitment after the NIR-boosted and MN-mediated cancer immunotherapy. Immune cell recruitment after the NIR-boosted and MN-mediated cancer.

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Immune cell recruitment after the NIR-boosted and MN-mediated cancer immunotherapy. Immune cell recruitment after the NIR-boosted and MN-mediated cancer immunotherapy. (A) Representative quantitative analysis of DCs (CD11c+ and PIR-A/B+) infiltrated in the skin 3 days after treatments as assessed by flow cytometry. The indicated samples were treated with blank MN (blank), vaccine MN (MN), MN loaded with tumor lysate without GM-CSF and treated with NIR (NIR), and vaccine MN and treated with NIR (MN + NIR). a.u., arbitrary units. (B) Representative quantitative analysis of NK cells (CD49b+) in the skin upon transdermal cancer immunotherapy as assessed by flow cytometry. (C and D) Immunofluorescence staining and quantitative analysis of (C) CD11c+ DCs (scale bar, 100 μm) and (D) CD49b+ NK cells (scale bar, 100 μm). Statistical significance was calculated by Student’s t test (*P < 0.05; **P < 0.01). Asterisks indicate significant differences between the MN + NIR group and all other treatment groups. Data points represent mean ± SD (n = 3). Error bars indicate SD. Yanqi Ye et al. Sci. Immunol. 2017;2:eaan5692 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works