Postconditioning inhibits Ca2+-induced mPTP opening.

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Postconditioning inhibits Ca2+-induced mPTP opening. Postconditioning inhibits Ca2+-induced mPTP opening. (A) A typical example of Ca2+-induced mPTP opening recordings in mitochondria that were isolated from control (Ctrl), preconditioned (PreC) and postconditioned (PostC) animals. mPTP opening was defined as a massive release of Ca2+ by mitochondria after a progressive Ca2+ overload of the suspension medium. The Ca2+ required for mPTP opening was significantly increased compared with animals in the control group. Postconditioning, preconditioning and NIM811 (a nonimmunosuppressive derivative of cyclosporin A that specifically inhibits opening of the mPTP) inhibited mPTP opening equally. (B) Inhibition of the mPTP resulted in a significant reduction of infarct size. The area of necrosis was reduced by a comparable extent in the preconditioned, postconditioned and NIM811 groups. *P<0.05 vs control. Nathan Mewton et al. Dis. Model. Mech. 2010;3:39-44 ©2010 by The Company of Biologists Limited