Nuclear Receptors Orchestrate Detoxification Pathways

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Nuclear Receptors Orchestrate Detoxification Pathways Jayanta Roy-Chowdhury, Joseph Locker, Namita Roy-Chowdhury Developmental Cell Volume 4, Issue 5, Pages 607-608 (May 2003) DOI: 10.1016/S1534-5807(03)00131-X

Figure 1 Bilirubin Metabolism Bilirubin uptake, intracellular storage, conjugation with glucuronic acid, and biliary excretion are mediated by SLC21A6, GSTs, UGT1A1, and ABC-C2 (MRP2), respectively. The genes for each step of this pathway are coordinately induced by activated CAR. Developmental Cell 2003 4, 607-608DOI: (10.1016/S1534-5807(03)00131-X)