Hyperinsulinemic-euglycemic clamps revealed that obese TPL2KO mice have an improved insulin sensitivity compared with obese WT mice. Hyperinsulinemic-euglycemic.

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Hyperinsulinemic-euglycemic clamps revealed that obese TPL2KO mice have an improved insulin sensitivity compared with obese WT mice. Hyperinsulinemic-euglycemic clamps revealed that obese TPL2KO mice have an improved insulin sensitivity compared with obese WT mice. A: Temporal pattern of plasma glucose concentrations maintained during the hyperinsulinemic-euglycemic clamp. B: Steady-state whole-body glucose infusion (GINF) rate during hyperinsulinemic-euglycemic clamps. C: Basal and insulin-stimulated hepatic glucose output (HGO). D: Rate of glucose disappearance (Rd). E: Insulin-stimulated muscle glucose uptake. F: Insulin-stimulated white adipose tissue glucose uptake (n = 5–6). *P < 0.05. The error bars designate the SE. James W. Perfield II et al. Diabetes 2011;60:1168-1176 ©2011 by American Diabetes Association