Hemodialysis and L-arginine, but not D-arginine, correct renal failure-associated endothelial dysfunction  Malcolm F. Hand, William G. Haynes, David J.

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Hemodialysis and L-arginine, but not D-arginine, correct renal failure-associated endothelial dysfunction  Malcolm F. Hand, William G. Haynes, David J. Webb  Kidney International  Volume 53, Issue 4, Pages 1068-1077 (April 1998) DOI: 10.1111/j.1523-1755.1998.00851.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Effect of norepinephrine on vein size in 12 patients with end-stage renal failure (•) and 8 age and sex matched control subjects (○). There is no significant difference in responsiveness to infusion of norepinephrine (P = 0.96). Kidney International 1998 53, 1068-1077DOI: (10.1111/j.1523-1755.1998.00851.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Percentage reversal of venoconstriction by acetylcholine (A) in 8 patients before hemodialysis (□) and 8 control subjects (○) and (B) in 8 patients before (□) and after hemodialysis (▪). Before hemodialysis the response is impaired compared with that of control subjects (P = 0.01) and is enhanced by hemodialysis (P = 0.001). Kidney International 1998 53, 1068-1077DOI: (10.1111/j.1523-1755.1998.00851.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Percentage reversal of venoconstriction by glyceryl trinitrate in 8 patients with end-stage renal failure before (□) and after hemodialysis (▪), and in 8 control subjects (○). There are no significant differences between the response before and after hemodialysis (P = 0.88) or to control subjects (P = 0.52). Kidney International 1998 53, 1068-1077DOI: (10.1111/j.1523-1755.1998.00851.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 Percentage reversal of venoconstriction by acetylcholine before hemodialysis in 8 patients with end-stage renal failure with (•) and without co-infusion of L-arginine (○) and in 4 patients before hemodialysis with (▪) and without co-infusion of D-arginine (□). The response to acetylcholine is enhanced with co-infusion of L-arginine (P = 0.09). However, there is no significant change in the response to acetylcholine when D-arginine is infused pre-hemodialysis (P = 0.98). Kidney International 1998 53, 1068-1077DOI: (10.1111/j.1523-1755.1998.00851.x) Copyright © 1998 International Society of Nephrology Terms and Conditions