Hemodialysis and L-arginine, but not D-arginine, correct renal failure-associated endothelial dysfunction Malcolm F. Hand, William G. Haynes, David J.

Slides:

Advertisements

Similar presentations

Renal Stress Testing in the Assessment of Kidney Disease Lakhmir S. Chawla, Claudio Ronco Kidney International Reports Volume 1, Issue 1, Pages (May.

Advertisements

Volume 63, Issue 4, Pages (April 2003)

David H.P. Streeten, MB, DPhil

A.M. Thompson, T.G. Pickering Kidney International

Volume 54, Issue 2, Pages (August 1998)

Long-term evolution of cardiomyopathy in dialysis patients

Beta blockers in the management of chronic kidney disease

Use of hemodialysis and hemoperfusion in poisoned patients

Anemia management in chronic kidney disease

End-stage renal disease in developing countries

Volume 83, Issue 3, Pages (March 2013)

Stem cells for kidney repair: useful tool for acute renal failure?

Kidney transplantation in a low-resource setting: Nigeria experience

Volume 61, Issue 4, Pages (April 2002)

Progression of renal failure and hypertensive nephrosclerosis

Volume 75, Issue 11, Pages (June 2009)

Mortality caused by sepsis in patients with end-stage renal disease compared with the general population Mark J. Sarnak, Bertrand L. Jaber Kidney International

Burden of chronic kidney disease: North Africa

Smoking and cardiovascular outcomes in dialysis patients: The United States Renal Data System Wave 2 Study1,2 Robert N. Foley, Charles A. Herzog, Allan.

Peripheral microvascular parameters in the nephrotic syndrome

Volume 63, Issue 2, Pages (February 2003)

Comorbidity and confounding in end-stage renal disease

Early mortality in dialysis and adequacy of predialysis renal care: the picture is more complex than we thought Nicolas Rognant, Maurice Laville Kidney.

Volume 64, Issue 1, Pages (July 2003)

Lipid redistribution in renal dysfunction

Volume 70, Issue 11, Pages (December 2006)

Joseph W. Eschbach, John W. Adamson Kidney International

Manjula Kurella Tamura, Kristine Yaffe Kidney International

Nephrology Crosswords: Hemodialysis

The epidemiology of chronic kidney disease

Prevention of renal failure: The Malaysian experience

Gentamicin pharmacokinetics during slow daily home hemodialysis

Volume 71, Issue 6, Pages (March 2007)

Volume 70, Issue 12, Pages (December 2006)

Blood pressure targets in hemodialysis patients

Amit X. Garg, William F. Clark, R. Brian Haynes, Andrew A. House

Volume 62, Issue 4, Pages (October 2002)

Fructose intake as a risk factor for kidney stone disease

Volume 69, Issue 12, Pages (June 2006)

Volume 69, Issue 3, Pages (February 2006)

Kidney failure and the gut: p-cresol and the dangers from within

Presentation of the 2003 Jean Hamburger Award to Robert W. Schrier

Alternate-day dialysis may be needed for hemodialysis patients

Volume 87, Issue 1, Pages (January 2015)

Long-term evolution of cardiomyopathy in dialysis patients

Racial disparities in access to transplantation: a tough nut to crack

Lynda Anne Szczech, Ira L. Lazar Kidney International

Volume 54, Issue 2, Pages (August 1998)

Daily nocturnal home hemodialysis

Wei-Teing Chen, Horng-Chin Yan, Fu-Chiu Yu Kidney International

Current status of maintenance hemodialysis in Beijing, China

Organ transplantation goes to the movies

The Iranian model of living renal transplantation

The Danish Renal Biopsy Register

Volume 80, Issue 10, Pages (November 2011)

Volume 57, Issue 2, Pages (October 2000)

Is complement a target for therapy in renal disease?

ANCA comes of age—but with caveats

Volume 68, Issue 1, Pages (July 2005)

Volume 70, Issue 5, Pages (September 2006)

H.J. Chin, H. Ro, H.J. Lee, K.Y. Na, D.-W. Chae Kidney International

Volume 70, Issue 10, Pages (November 2006)

The International Pediatric Peritonitis Registry: Starting to walk

Volume 69, Issue 8, Pages (April 2006)

Hemodialysis access failure: a call to action—revisited

Familial phenotype differences in PKD11

Volume 60, Issue 6, Pages (December 2001)

Stephen Pastan, J. Michael Soucie, William M. McClellan

A. Lauschke, U.K.M. Teichgräber, U. Frei, K.-U. Eckardt

Epidemiologic data of renal diseases from a single unit in China: Analysis based on 13,519 renal biopsies Lei-Shi Li, Zhi-Hong Liu Kidney International

Presentation transcript:

Hemodialysis and L-arginine, but not D-arginine, correct renal failure-associated endothelial dysfunction Malcolm F. Hand, William G. Haynes, David J. Webb Kidney International Volume 53, Issue 4, Pages 1068-1077 (April 1998) DOI: 10.1111/j.1523-1755.1998.00851.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Effect of norepinephrine on vein size in 12 patients with end-stage renal failure (•) and 8 age and sex matched control subjects (○). There is no significant difference in responsiveness to infusion of norepinephrine (P = 0.96). Kidney International 1998 53, 1068-1077DOI: (10.1111/j.1523-1755.1998.00851.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Percentage reversal of venoconstriction by acetylcholine (A) in 8 patients before hemodialysis (□) and 8 control subjects (○) and (B) in 8 patients before (□) and after hemodialysis (▪). Before hemodialysis the response is impaired compared with that of control subjects (P = 0.01) and is enhanced by hemodialysis (P = 0.001). Kidney International 1998 53, 1068-1077DOI: (10.1111/j.1523-1755.1998.00851.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Percentage reversal of venoconstriction by glyceryl trinitrate in 8 patients with end-stage renal failure before (□) and after hemodialysis (▪), and in 8 control subjects (○). There are no significant differences between the response before and after hemodialysis (P = 0.88) or to control subjects (P = 0.52). Kidney International 1998 53, 1068-1077DOI: (10.1111/j.1523-1755.1998.00851.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 Percentage reversal of venoconstriction by acetylcholine before hemodialysis in 8 patients with end-stage renal failure with (•) and without co-infusion of L-arginine (○) and in 4 patients before hemodialysis with (▪) and without co-infusion of D-arginine (□). The response to acetylcholine is enhanced with co-infusion of L-arginine (P = 0.09). However, there is no significant change in the response to acetylcholine when D-arginine is infused pre-hemodialysis (P = 0.98). Kidney International 1998 53, 1068-1077DOI: (10.1111/j.1523-1755.1998.00851.x) Copyright © 1998 International Society of Nephrology Terms and Conditions