B-cell epitopes as a screening instrument for persistent cow's milk allergy Kirsi-Marjut Järvinen, MD, PhD, Kirsten Beyer, MD, Leticia Vila, MD, Pantipa.

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Presentation transcript:

B-cell epitopes as a screening instrument for persistent cow's milk allergy Kirsi-Marjut Järvinen, MD, PhD, Kirsten Beyer, MD, Leticia Vila, MD, Pantipa Chatchatee, MD, Paula J. Busse, MD, Hugh A. Sampson, MD Journal of Allergy and Clinical Immunology Volume 110, Issue 2, Pages 293-297 (August 2002) DOI: 10.1067/mai.2002.126080 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 An example of binding to decapeptides of cow's milk proteins of serum IgE antibodies by a patient with persistent CMA (upper rows) and a patient with transient CMA (lower rows) . Numbers indicate the residues corresponding to the peptide. α-lac, α-Lactalbumin; β-lac, β-lactoglobulin. Journal of Allergy and Clinical Immunology 2002 110, 293-297DOI: (10.1067/mai.2002.126080) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 2 Numbers of patients showing binding to each major IgE-binding epitope (represented as AA residues) of αs1-casein (A) , αs2-casein (B) , κ-casein (C) , and whey proteins (D) . Patients with persistent CMA are shown in filled bars , and those with transient CMA are shown in open bars . The total number of patients in each group is 10. Journal of Allergy and Clinical Immunology 2002 110, 293-297DOI: (10.1067/mai.2002.126080) Copyright © 2002 Mosby, Inc. Terms and Conditions