An IRKO in the Podo: Impaired Insulin Signaling in Podocytes and the Pathogenesis of Diabetic Nephropathy Susan B. Gurley, Thomas M. Coffman Cell Metabolism

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An IRKO in the Podo: Impaired Insulin Signaling in Podocytes and the Pathogenesis of Diabetic Nephropathy Susan B. Gurley, Thomas M. Coffman Cell Metabolism Volume 12, Issue 4, Pages 311-312 (October 2010) DOI: 10.1016/j.cmet.2010.09.007 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Impaired Insulin Receptor Signaling in Podocytes May Promote the Development of Nephropathy through Two Mechanisms One pathway is through effects on cytoskeletal function. In the second pathway, the absence of insulin receptor signaling may leave the podocyte susceptible to apoptosis, which can cause proteinuria, instability of the glomerular tuft, and sclerosis. Cell Metabolism 2010 12, 311-312DOI: (10.1016/j.cmet.2010.09.007) Copyright © 2010 Elsevier Inc. Terms and Conditions