Allergy or tolerance in children sensitized to peanut: Prevalence and differentiation using component-resolved diagnostics  Nicolaos Nicolaou, MD, MPhil,

Slides:



Advertisements
Similar presentations
Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,
Advertisements

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,
Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,
Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.
Characteristics of childhood peanut allergy in the Australian Capital Territory, 1995 to 2007 Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Keith B.G.
Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity  Abena S. Amoah, MSc, Benedicta.
Staphylococcus aureus sensitization and allergic disease in early childhood: Population- based birth cohort study  Aida Semic-Jusufagic, MD, Claus Bachert,
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Dose-time-response relationship in peanut allergy using a human model of passive cutaneous anaphylaxis  Anja P. Mose, MD, Charlotte G. Mortz, MD, PhD,
Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O
Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study  Anna.
The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy  Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.
The impact of government advice to pregnant mothers regarding peanut avoidance on the prevalence of peanut allergy in United Kingdom children at school.
Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Ann-Marie M. Schoos, MD, PhD, Jacob D
Is the prevalence of peanut allergy increasing
Incident asthma and Mycoplasma pneumoniae: A nationwide cohort study
Is 9 more than 2 also in allergic airway inflammation?
Desensitization to Chemotherapeutic Agents
Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study  Anna.
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Disaggregating asthma: Big investigation versus big data
Robert G. Hamilton, PhD, John Oppenheimer, MD 
Adnan Custovic, MD, PhD, Hans-Joachim Sonntag, MRes, Iain E
Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J
Allergy testing in predicting outcome of open food challenge to peanut
Peter M. Wolfgram, MD, David B. Allen, MD 
Etiology of asthma exacerbations
Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O
Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA 
The Editors' Choice Journal of Allergy and Clinical Immunology
Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation  Leif Bjermer, MD  Journal of Allergy.
Bifidobacterium pseudocatenulatum is associated with atopic eczema: A nested case- control study investigating the fecal microbiota of infants  Claudia.
Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management  Scott H. Sicherer, MD, Hugh A. Sampson, MD  Journal.
Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies 
A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity  Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,
What is an “eosinophilic phenotype” of asthma?
Dose-time-response relationship in peanut allergy using a human model of passive cutaneous anaphylaxis  Anja P. Mose, MD, Charlotte G. Mortz, MD, PhD,
Cephalosporin Side Chain Cross-reactivity
Audrey DunnGalvin, PhD, L. M
H. William Kelly, PharmD  Journal of Allergy and Clinical Immunology 
Autophagy: Nobel Prize 2016 and allergy and asthma research
Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment
Advances in the approach to the patient with food allergy
Geographic variability in childhood asthma prevalence in Chicago
Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L
One step forward, 2 steps back: The enigma of preschool wheeze
Anne M. Fitzpatrick, PhD, Youngja Park, PhD, Lou Ann S
Sublingual versus oral immunotherapy for peanut-allergic children: A retrospective comparison  Stacy J. Chin, MD, Brian P. Vickery, MD, Michael D. Kulis,
Association between climate factors, pollen counts, and childhood hay fever prevalence in the United States  Jonathan I. Silverberg, MD, PhD, MPH, Marc.
Washing the dog reduces dog allergen levels, but the dog needs to be washed twice a week  Tessa Hodson, BSc, Adnan Custovic, MD, Angela Simpson, MD, Martin.
Day-care attendance, position in sibship, and early childhood wheezing: A population- based birth cohort study  Nicolaos C. Nicolaou, MD, MPhil, Angela.
Peanut oral immunotherapy decreases IgE to Ara h 2 and Ara h 6 but does not enhance sensitization to cross-reactive allergens  Riikka Uotila, MD, Anna.
Jessica H. Savage, MD, MHS, Elizabeth C. Matsui, MD, MHS, Robert A
Atopic endotype in childhood
William J. Sheehan, MD, Helen A
Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity  Abena S. Amoah, MSc, Benedicta.
Macrolide antibiotics and asthma treatment
Asthma: The past, future, environment, and costs
Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother  Sabine Flicker, PhD, Katharina Marth, MD, Heinz.
Personal and parental nativity as risk factors for food sensitization
Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing  Danielle C.M. Belgrave,
Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity  Abena S. Amoah, MSc, Benedicta.
Evolution of IgE responses to multiple allergen components throughout childhood  Rebecca Howard, MSc, Danielle Belgrave, PhD, Panagiotis Papastamoulis,
The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy  Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.
Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood  Adnan Custovic, MD, PhD, Lars Soderstrom,
Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease  Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD,
Natural history of cow’s milk allergy
Primary prevention of asthma and allergy
Presentation transcript:

Allergy or tolerance in children sensitized to peanut: Prevalence and differentiation using component-resolved diagnostics  Nicolaos Nicolaou, MD, MPhil, Maryam Poorafshar, PhD, Clare Murray, MD, Angela Simpson, MD, Henric Winell, MSc, Gina Kerry, RN, Annika Härlin, MSc, Ashley Woodcock, MD, FMedSci, Staffan Ahlstedt, PhD, Adnan Custovic, MD, PhD, FRCP  Journal of Allergy and Clinical Immunology  Volume 125, Issue 1, Pages 191-197.e13 (January 2010) DOI: 10.1016/j.jaci.2009.10.008 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 The study profile. Journal of Allergy and Clinical Immunology 2010 125, 191-197.e13DOI: (10.1016/j.jaci.2009.10.008) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Empirical cumulative distribution functions. Green and yellow lines represent peanut-tolerant subjects and subjects with peanut allergy, respectively. n, Native; r, recombinant. Journal of Allergy and Clinical Immunology 2010 125, 191-197.e13DOI: (10.1016/j.jaci.2009.10.008) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Variable importance. High positive values of the importance measure indicate a high variable importance, whereas small positive or negative values indicate that a variable is irrelevant for discrimination. n, Native; r, recombinant. Journal of Allergy and Clinical Immunology 2010 125, 191-197.e13DOI: (10.1016/j.jaci.2009.10.008) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Pattern of component spots on microarray membrane Pattern of component spots on microarray membrane. Pure components (n, Native; r, recombinant) from peanut (Ara h 1-3 and 8), grass (Phl p 1, 4, 5b, 7, and 12) and others (Bet v 1, Pru p 3, and CCD) were immobilized in spots on a capillary flow membrane. Journal of Allergy and Clinical Immunology 2010 125, 191-197.e13DOI: (10.1016/j.jaci.2009.10.008) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Characteristic fluorometric results of microarrays Characteristic fluorometric results of microarrays. Pictures of fluorometric component recognition patterns in subjects with distinct clinical phenotypes. A, Subject not recognizing any components (negative control). B, Subject recognizing all components (with peanut allergy and hay fever). C, Subject recognizing only major peanut components (with peanut allergy). D, Subject recognizing only grass and cross-reacting components (with hay fever and asymptomatic peanut sensitization). Journal of Allergy and Clinical Immunology 2010 125, 191-197.e13DOI: (10.1016/j.jaci.2009.10.008) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Scatter plot matrix contains all the pairwise scatter plots of the components' fold-change values. Green and yellow dots represent peanut-tolerant subjects and subjects with peanut allergy, respectively. n, Native; r, recombinant. Journal of Allergy and Clinical Immunology 2010 125, 191-197.e13DOI: (10.1016/j.jaci.2009.10.008) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Parallel coordinate plot Parallel coordinate plot. Each line represents a subject's fold-change values across all components. Green and yellow lines represent peanut-tolerant subjects and subjects with peanut allergy, respectively. Max, Maximum; Min, minimum; n, native; r, recombinant. Journal of Allergy and Clinical Immunology 2010 125, 191-197.e13DOI: (10.1016/j.jaci.2009.10.008) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions