Allergy or tolerance in children sensitized to peanut: Prevalence and differentiation using component-resolved diagnostics Nicolaos Nicolaou, MD, MPhil,

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Presentation transcript:

Allergy or tolerance in children sensitized to peanut: Prevalence and differentiation using component-resolved diagnostics Nicolaos Nicolaou, MD, MPhil, Maryam Poorafshar, PhD, Clare Murray, MD, Angela Simpson, MD, Henric Winell, MSc, Gina Kerry, RN, Annika Härlin, MSc, Ashley Woodcock, MD, FMedSci, Staffan Ahlstedt, PhD, Adnan Custovic, MD, PhD, FRCP Journal of Allergy and Clinical Immunology Volume 125, Issue 1, Pages 191-197.e13 (January 2010) DOI: 10.1016/j.jaci.2009.10.008 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 The study profile. Journal of Allergy and Clinical Immunology 2010 125, 191-197.e13DOI: (10.1016/j.jaci.2009.10.008) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Empirical cumulative distribution functions. Green and yellow lines represent peanut-tolerant subjects and subjects with peanut allergy, respectively. n, Native; r, recombinant. Journal of Allergy and Clinical Immunology 2010 125, 191-197.e13DOI: (10.1016/j.jaci.2009.10.008) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Variable importance. High positive values of the importance measure indicate a high variable importance, whereas small positive or negative values indicate that a variable is irrelevant for discrimination. n, Native; r, recombinant. Journal of Allergy and Clinical Immunology 2010 125, 191-197.e13DOI: (10.1016/j.jaci.2009.10.008) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Pattern of component spots on microarray membrane Pattern of component spots on microarray membrane. Pure components (n, Native; r, recombinant) from peanut (Ara h 1-3 and 8), grass (Phl p 1, 4, 5b, 7, and 12) and others (Bet v 1, Pru p 3, and CCD) were immobilized in spots on a capillary flow membrane. Journal of Allergy and Clinical Immunology 2010 125, 191-197.e13DOI: (10.1016/j.jaci.2009.10.008) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Characteristic fluorometric results of microarrays Characteristic fluorometric results of microarrays. Pictures of fluorometric component recognition patterns in subjects with distinct clinical phenotypes. A, Subject not recognizing any components (negative control). B, Subject recognizing all components (with peanut allergy and hay fever). C, Subject recognizing only major peanut components (with peanut allergy). D, Subject recognizing only grass and cross-reacting components (with hay fever and asymptomatic peanut sensitization). Journal of Allergy and Clinical Immunology 2010 125, 191-197.e13DOI: (10.1016/j.jaci.2009.10.008) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Scatter plot matrix contains all the pairwise scatter plots of the components' fold-change values. Green and yellow dots represent peanut-tolerant subjects and subjects with peanut allergy, respectively. n, Native; r, recombinant. Journal of Allergy and Clinical Immunology 2010 125, 191-197.e13DOI: (10.1016/j.jaci.2009.10.008) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Parallel coordinate plot Parallel coordinate plot. Each line represents a subject's fold-change values across all components. Green and yellow lines represent peanut-tolerant subjects and subjects with peanut allergy, respectively. Max, Maximum; Min, minimum; n, native; r, recombinant. Journal of Allergy and Clinical Immunology 2010 125, 191-197.e13DOI: (10.1016/j.jaci.2009.10.008) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions