Formation of papilloma lesions in the UroIICre+Fgfr3+/K644EK-RasG12D/+ model. Formation of papilloma lesions in theUroIICre+Fgfr3+/K644EK-RasG12D/+model.

Slides:

Advertisements

Similar presentations

Mitochondria localize to both the front and the rear of neutrophils.

Advertisements

Immuno-gold localisation of COPI in N. gruberi cells.

Osteosarcoma histology.

Scanning electron microscopy analysis of EGK-I to -V chick embryos.

The pathophysiological processes linked to kidney disease.

ILK knockdown decreases mTOR signaling in PKD kidneys.

mTOR downregulation, but not autophagy, reduces VAP(P58S) aggregation.

Fig. 1. Representative images of the four cell lines using fluorescence microscopy. Representative images of the four cell lines using fluorescence microscopy.

Fig. 4. smc3 regulates the expression of cx43 in regenerating fins.

Representative illustrations of a sagittal lung section stained with H&E in a control and a CS-exposed mouse after 6 months. Representative illustrations.

Fig. 2. Morphological changes of cultured adherent fibroblastic cells after OA treatment related to actin microfilament reorganization.(A) Cells observed.

Nephrogenesis in vitro can be rescued in 3D co-cultures by siRNA treatment of Renca cells. Nephrogenesis in vitro can be rescued in 3D co-cultures by siRNA.

Differential Cre-ERT activity and PTEN deletion in endometrial epithelial and stromal compartments. Differential Cre-ERT activity and PTEN deletion in.

Loss of RBP-J results in a reduction of segments due to total branch loss with age. Loss of RBP-J results in a reduction of segments due to total branch.

Total and differential cell counting in the broncho-alveolar lavage of mice exposed to CS or air during 3 or 6 months. Total and differential cell counting.

Fig. 6. Cross-section of the stomach wall and spiral intestine of the embryo, stained with PAS. (A) Surface of the stomach wall (SW) and ingested material.

Inflammation is associated with increased basal-cell plasticity in the Nkx3.1 mutant prostate. Inflammation is associated with increased basal-cell plasticity.

Fig. 1. Mitochondrial internalization in cardiomyocytes.

Fig. 1. Loss of PC following INT depletion

Fig. 1. Morphological and growth characterization of hBMCs and hPDCs

Expression of tomoregulin-1 in wild-type and cardiac hypertrophy mouse myocardium. Expression of tomoregulin-1 in wild-type and cardiac hypertrophy mouse.

Hipk induces cell spreading.

Challenge with oxazolone results in epithelial hyperplasia and influx of inflammatory cells into the epidermis and dermis and keratosis as observed in.

PfSec13 does not co-localize with P. falciparum heterochromatin.

Characterization of Col1a1FRT-STOP-FRT-Cre-ER-T2 mice.

Secondary storage of GM2 ganglioside and cholesterol in Fuca1-deficient mice. Secondary storage of GM2 ganglioside and cholesterol in Fuca1-deficient mice.

Obesity affected the metabolic response to stroke.

Fgfr3 mutation is not the sole driver of tumorigenesis in the bladder.

Fig. 5. The bulk of Cep135 localizes distantly from Sas-6 and STIL

Fig. 6. Comparison of Plk4 with Sas-6 localization

Effects of doxorubicin and epirubicin on proliferation and apoptosis in the hyperplastic livers of transgenic zebrafish larvae. Effects of doxorubicin.

Hipk induces overgrowths in Drosophila imaginal discs.

Fig. 7. Lhx1-RNAi reduces the eye size

Fig. 2. Centrosomal proteins display distinct localizations and radial distances from centriole walls.U2OS cells were fixed and stained with the indicated.

Fig. 3. Rnd proteins induce stronger responses in subconfluent endothelial cells.HUVECs were transfected with Rnd1, Rnd2, Rnd3 or GFP-encoding plasmids.

Fig. 7. Representative images of control (Cas9+GFP) and Cas9+gRNA+GFP co-injected embryos on day 4 of culture, showing nuclear-imported GFP (green) and.

Detection of nuclear foci by FISH on frozen sections of diaphragm muscle prepared from 2-month-old DMSXL mice. Detection of nuclear foci by FISH on frozen.

Fig. 6. STK35 KO mice show ovary defects.

The mutants exhibit congenital hypothyroidism.

Characterization of zebrafish muscle wasting in krasG12V-induced HCC zebrafish. 4-month-old male adult krasG12V and WT zebrafish were treated with dox.

The effect of TDP-43A315T expression at the synapse.

Elevation of ERK downstream signaling is associated with tumor formation in the bladder and in papilloma formation. Elevation of ERK downstream signaling.

Detection of gene recombination in endoxifen- or Adeno-Cre-induced tumours. Detection of gene recombination in endoxifen- or Adeno-Cre-induced tumours.

Cellular reaction to intraventricular DMSO injection.

Fig. 2. Sufficient rate of recombination in embryonic NSCs and NPCs of Emx1cre knock-in mice.(A) Breeding schemes to generate mice with the Emx1cre locus.

Rgs16::GFP expression in pancreatic neoplasia.

Impaired elastogenesis in Ltbp4S−/−;Fibulin-4R/R mice with reduced interaction of Ltbp-4L and fibulin-4. Impaired elastogenesis in Ltbp4S−/−;Fibulin-4R/R.

Effect of the plastid translation inhibitor Spec on LR development

Fig. 1. Loss of PC following INT depletion

Tumor location determines response to intravenous FOLFIRINOX chemotherapy. Tumor location determines response to intravenous FOLFIRINOX chemotherapy. (A)

Nerve conduction slowing and DRG sensory neuron and nuclear atrophy in 16-week-old diabetic mice. Nerve conduction slowing and DRG sensory neuron and nuclear.

Fig. 3. Enhanced EGFR signaling in Rhbdf2P159L/P159L mice.

Gα12 is not required for hepatic cystogenosis induced by Pkd1 knockout

Fig. 2. iPSCs produce functional osteoblasts.

Ibm1 and edm2 mutants generate more stomatal divisions in the leaf epidermis. ibm1 and edm2 mutants generate more stomatal divisions in the leaf epidermis.

IGF1R is present in endometrial luminal epithelium at the receptive phase. IGF1R is present in endometrial luminal epithelium at the receptive phase. Endometrial.

Peroxisome speeds were slower in patient and control cells.

Fig. 2. Acetylation stiffens primary cilia.

Proliferation on soft matrices is decoupled from myosin light chain phosphorylation, cell tractions, and focal adhesions. Proliferation on soft matrices.

Fig. 3. MO-mediated smc3 knockdown results in reduced regenerate length, segment length and cell proliferation. MO-mediated smc3 knockdown results in reduced.

The BRCA1 aggregates exclude large nuclear structures.

Depletion of COPI protein inhibits cis to trans cisternal maturation.

Adult Acvr1;Trp53DCKO lenses form vascularized, tumor-like structures at their posterior poles. 4-month-old Trp53CKO and Acvr1;Trp53DCKO lenses were sectioned.

The absence of host Fbln5 results in increased apoptosis and decreased proliferation in Pan02 tumors. The absence of host Fbln5 results in increased apoptosis.

Lack of Ctip2 is associated with impaired proliferation and delayed onset of differentiation during early stages of epidermal development. Lack of Ctip2.

BMOL3 LPCs can differentiate towards the hepatocyte lineage.

Disruption of the tubule formation by immortalized cells during nephrogenesis in vitro. Disruption of the tubule formation by immortalized cells during.

2DG suppresses of lamellipodia and filopodia and causes disorganization of F-actin filaments in murine endothelial cells. 2DG suppresses of lamellipodia.

Tsg protein stimulates endothelial cell migration, proliferation and collagen gel spheroid sprouting. Tsg protein stimulates endothelial cell migration,

Upon challenge with oxazolone, human leukocytes (mainly consisting of T cells) infiltrate the dermis and epidermis. Upon challenge with oxazolone, human.

Presentation transcript:

Formation of papilloma lesions in the UroIICre+Fgfr3+/K644EK-RasG12D/+ model. Formation of papilloma lesions in theUroIICre+Fgfr3+/K644EK-RasG12D/+model. Papilloma samples are from 12-month-old UroIICre+Fgfr3+/K644EK-RasG12D/+ mice. H&E staining shows the formation of a papilloma (A), in which BrdU immunoreactivity demonstrated cell proliferation (B). Upregulation of pERK1/2 was observed (C), as was observed in the urothelium (Fig. 1O). However, upregulation of Sprouty2 was not present in UroIICre+Fgfr3+/K644EK-RasG12D/+ mice (D). Neither pAKT(Ser473) (E) nor p-mTOR (F) was upregulated in papillomas formed in UroIICre+Fgfr3+/K644EK-RasG12D/+ mice. GFP imaging indicated Cre-recombined cells in the papilloma (G). 14× magnification was used. Scale bar: 200 μm in all panels except for G. Imran Ahmad et al. Dis. Model. Mech. 2011;4:548-555 © 2011. Published by The Company of Biologists Ltd