CD4 expressing CD161 and CD8 expressing CD161int are preserved in CVID

Slides:

Advertisements

Similar presentations

Recapping: Distribution of data.

Advertisements

High-dimensional analysis of lymphoid CD4+ T cells identified distinct TFH cell subsets in HIV+ patients and HCs. High-dimensional analysis of lymphoid.

Dominant IL-21 expression in TFH cells correlate with B cell pathology in HIV-infected LNs. Dominant IL-21 expression in TFH cells correlate with B cell.

Foxp3 induction dependent on cell cycle progression in vitro.

Box plot showing percentage change in early diastolic pulsed-Doppler mitral inflow (E)/early diastolic tissue Doppler velocity (E´) from pre– to post–balloon.

Expression analyses of KLK7 mRNA in the brains of AD patients

Les Lang Gastroenterology Volume 133, Issue 1, (July 2007)

Diminished suppressive potency of primary Treg clones from IPEXA384T patients. Diminished suppressive potency of primary Treg clones from IPEXA384T patients.

Les Lang Gastroenterology Volume 133, Issue 1, (July 2007)

Figure 3 B-cell amount and the frequency of various B-cell subtypes are differentially affected by FTY or DMF treatment B-cell amount and the frequency.

by Paolo Strati, Michael J. Keating, William G. Wierda, Xavier C

Maraviroc contributes to the restoration of the homeostasis of regulatory T-cell subsets in antiretroviral-naive HIV-infected subjects M.M. Pozo-Balado,

Box plot of subarachnoid space measurements at each gestational week of age. Box plot of subarachnoid space measurements at each gestational week of age.

Naïve B cells (CD19+CD27-), memory B cells (CD19+CD27+) and plasmablasts (PB CD27++) levels in patients with systemic sclerosis. Indicated points resemble.

MP cells are generated from naïve cells in the periphery.

Box plot of head circumference measurements at each gestational week of age. Box plot of head circumference measurements at each gestational week of age.

Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis

Figure 3 Age, pretreatment, sex, and leukopenia do not influence CD19+ cell repopulation Age, pretreatment, sex, and leukopenia do not influence CD19+

ALT-803 administration increases peripheral blood cell counts of lymphocyte subsets in cynomolgus monkeys. ALT-803 administration increases peripheral.

Human Treg cells express PlexinB1.

Heiko Lehrmann et al. JACEP 2018;j.jacep

Figure 3 Gene expression in CSF cell pellets

Sandra Hellberg, MSc, Ratnesh B

Alvin W. L. Schadenberg, MD, Theo van den Broek, MD, Marten A

Role of IL-27 in expression of PD-L1, LAG-3, and CTLA-4 depends on strength of α-CD3/28 signaling. Role of IL-27 in expression of PD-L1, LAG-3, and CTLA-4.

Comparison of absolute counts for a, b) white blood cells (WBC), c, d) neutrophils, e, f) monocytes, and g, h) eosinophils for 100 patients with lymphangioleiomyomatosis.

Postoperative changes in blood monocyte subsets.

Box-And-Whisker Plots

Figure 5 Increased B cell-activating factor (BAFF) levels are shared between immunomodulatory treatments Increased B cell-activating factor (BAFF) levels.

Functional analysis of clinical response to low-dose IL-2 in patients with refractory chronic graft-versus-host disease by Jennifer S. Whangbo, Haesook.

Figure 4 Shared and unique immune changes induced by multiple sclerosis (MS) immunomodulatory treatments Shared and unique immune changes induced by multiple.

Figure 2 Distinct changes to immunoprofile in autoimmune thyroid disease (AITD) and multiple sclerosis (MS)‏ Distinct changes to immunoprofile in autoimmune.

Figure 2 Reduced frequency of central memory CD4 T cells in patients with PML Reduced frequency of central memory CD4 T cells (CD4Tcm) (p < ), naive.

Figure 2 Flu immunization–induced changes in the proportions and absolute numbers of B cells and their relevant subpopulations Flu immunization–induced.

(A) HLA-E expression on the surface of CD14+ cells in patients with AS, HLA-B*2705, HLA-B*2709-positive and HLA-B27-negative HCs. Results are expressed.

Figure 1 BG-12 treatment reduced total circulating B cells and had variable effects on memory B cells BG-12 treatment reduced total circulating B cells.

(A) Absolute and (B) change from baseline in 6 min walk distance over time for all patients and by Down syndrome status. (A) Absolute and (B) change from.

Figure 1 CD52 expression on innate myeloid and lymphoid cell subsets

Blood Tfr cells show expression of follicular and regulatory markers.

Figure 3 Flu immunization–induced changes in the proportions and absolute numbers of RORγt-expressing CD4+ and CD8+ T cells Flu immunization–induced changes.

Figure 1 Flu immunization–induced changes in the proportions and absolute numbers of T cells and their relevant subpopulations Flu immunization–induced.

Effect of aging on sputum inflammation and asthma control

CD27 expression on bovine γδ and CD4 T cells ex vivo and in response to mitogen. CD27 expression on bovine γδ and CD4 T cells ex vivo and in response to.

AhR activation reduces lung DC gene and surface expression of DC-SIGN.

Stavros V. Konstantinides et al. JACC 2017;69:

IRF4 expression regulates the sensitivity of CD8+ T cells to IL-2, IL-15, and IL-7. IRF4 expression regulates the sensitivity of CD8+ T cells to IL-2,

Activation of CD56+ cells in patients infected with ZIKV

SYK activity is required for anti-IgM–induced CD86 expression.

MK-8628 modulates transcriptional signatures of activated T lymphocytes. MK-8628 modulates transcriptional signatures of activated T lymphocytes. Gene.

MK-8628 suppresses T lymphocyte proliferation.

Shared phenotype of CD4+CLA+CD103+ T cells from human blood and skin.

Figure 3 Alemtuzumab-induced changes in monocytes

IL-27 induces expression of multiple IR by CD8+ T cells.

Survival based on V gene mutation status and CD38 expression among B-CLL patients who stratify to the Rai intermediate risk category. Survival based on.

Fig. 1 Injury-type frequencies and handicap in injured M. analis ants.

Cox regression analysis of the proportion of patients remaining in remission during azathioprine treatment related to minimum observed white blood cell.

Melanoma patient monocytes have altered expression of inflammatory and surface markers. Melanoma patient monocytes have altered expression of inflammatory.

SLC30A8 and INS gene expression in mTECs and circulating islet-reactive CD8+ T cell frequencies in HLA-A2+ and HLA-A2− healthy donors. SLC30A8 and INS.

PAP- and PA2024-specific CTLs at week 0 (prior to sipuleucel-T infusion) and at weeks 6 and 26 post–sipuleucel-T treatment. PAP- and PA2024-specific CTLs.

Abnormal monocyte distribution and loss of HLA-DR in patients with stage IV melanoma. Abnormal monocyte distribution and loss of HLA-DR in patients with.

ESKM treatment does not affect leukocyte or HSC counts in HLA-A

Phenotypic diversity of individual multiple myeloma clones.

Mice treated with DC therapy and/or M-CSFR inhibition were protected from tumor rechallenge with combination therapy-treated mice displaying superior recall.

Increased frequency and number of KLL-specific clonotypes in tumors is associated with improved MCC-specific survival. Increased frequency and number of.

Establishing a positive correlation between CD5 expression and self-reactivity in BCR WT B-1 cells. Establishing a positive correlation between CD5 expression.

Mice with a B cell–specific deletion of Ets1 do not have increased CD4+ T cell activation. Mice with a B cell–specific deletion of Ets1 do not have increased.

Cell counts of immune infiltrate and expression of galectin-1 and galectin-3 in the short-, medium-, and long-term survival cohorts. Cell counts of immune.

Figure 4 Longitudinal analysis of peripheral immune cell composition Frequency of naive, central memory (Tcm), and effector memory (Tem) CD4 T cells over.

Intersubject distribution of eGFR slope (left) and mGFR slope (right).

Kaplan-Meier (K-M) curves of progression-free survival (PFS) of the entire cohort of patients with metastatic gastric cancer treated with RAD001. Kaplan-Meier.

Presentation transcript:

CD4 expressing CD161 and CD8 expressing CD161int are preserved in CVID CD4 expressing CD161 and CD8 expressing CD161int are preserved in CVID. Gating strategy for CD161+ CD4 T cells and CD161int CD8 T cells (A). CD4 expressing CD161 and CD8 expressing CD161int are preserved in CVID. Gating strategy for CD161+ CD4 T cells and CD161int CD8 T cells (A). Frequency (B) and absolute count (C) of CD4 T cells expressing CD161, and frequency (D) and absolute count (E) of CD8 T cells expressing intermediate levels of CD161 in healthy controls (n = 22), treatment-naive (n = 15), and IVIg-treated CVID patients [(B and D) n = 11; (C and E) n = 7]. The lines and whiskers represent the median and interquartile range respectively. *p < 0.05, **p < 0.01. Dominic Paquin-Proulx et al. ImmunoHorizons 2017;1:142-155 Copyright © 2017 The Authors