Effects of tumour size on response to treatment in the KPC model.

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Effects of tumour size on response to treatment in the KPC model. Effects of tumour size on response to treatment in the KPC model. Gemcitabine imparts a small yet significant survival benefit in mice with smaller tumours (our unpublished observations). Mice were enrolled on study when tumours reached 3-6 mm mean diameter. Mice were treated with either saline or gemcitabine (100 mg/kg body weight) intraperitoneally twice per week until end point. 12 mice were enrolled per cohort. The median survival post-enrolment is indicated for each cohort in the figure. The Log-rank test was conducted using GraphPad Prism (P=0.0236). Aarthi Gopinathan et al. Dis. Model. Mech. 2015;8:1185-1200 © 2015. Published by The Company of Biologists Ltd