Jacqueline A. Pongracic, MD, Rebecca Z. Krouse, MS, Denise C

Slides:

Advertisements

Similar presentations

Buffering airway acid decreases exhaled nitric oxide in asthma Benjamin Gaston, MD, Robin Kelly, RN, Peter Urban, RN, Lei Liu, PhD, Edward M. Henderson,

Advertisements

Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations Stephen J. Teach, MD, MPH, Michelle.

Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children Susan V. Lynch, PhD, Robert A. Wood, MD, Homer.

Journal of Allergy and Clinical Immunology

Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban.

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

Winter birth in inner-city asthmatic children is associated with increased food allergen sensitization risk J. Andrew Bird, MD, Julie Wang, MD, Cynthia.

Advances in Diagnosing Peanut Allergy

A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy Satya D. Narisety,

Risk of an asthma exacerbation after bariatric surgery in adults

Asthma morbidity among inner-city adolescents receiving guidelines-based therapy: Role of predictors in the setting of high adherence Rebecca S. Gruchalla,

Päivi M. Salo, PhD, Samuel J

Asthma phenotypes in inner-city children

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children Susan V. Lynch, PhD, Robert A. Wood, MD, Homer.

The nasal methylome and childhood atopic asthma

Caregivers report a wide variety of early signs and symptoms of impending asthma exacerbations that are not different between preschool and school-aged.

Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study John M. Brehm, MD, MPH, Brooke Schuemann, BS,

Reassessment of Omalizumab-Dosing Strategies and Pharmacodynamics in Inner-City Children and Adolescents Christine A. Sorkness, PharmD, Jeremy J. Wildfire,

Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations Stephen J. Teach, MD, MPH, Michelle.

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Allergy testing in predicting outcome of open food challenge to peanut

Andrew H. Liu, MD, Denise C. Babineau, PhD, Rebecca Z

DNA methylation and childhood asthma in the inner city

Advances in Diagnosing Peanut Allergy

Cytokine response after severe respiratory syncytial virus bronchiolitis in early life Mario Castro, MD, MPH, Toni Schweiger, RN, Huiquing Yin-DeClue,

George T. O'Connor, MD, MS, Susan V. Lynch, PhD, Gordon R

William J. Calhoun, MD, Tmirah Haselkorn, PhD, Dave P

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy Satya D. Narisety,

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Ronald L. Sorkness, PhD, Edward M

Reply Journal of Allergy and Clinical Immunology

Stephen J. Teach, MD, MPH, Peter J. Gergen, MD, MPH, Stanley J

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Weiguo Chen, PhD, Gurjit K. Khurana Hershey, MD, PhD

Asthma in the inner city: The perspective of the National Institute of Allergy and Infectious Diseases Alkis Togias, MD, Matthew J. Fenton, PhD, Peter.

Rachel Enriquez, RN, PhD, Marie R. Griffin, MD, MPH, Kecia N

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Robert A. Wood, MD, Alkis Togias, MD, Jeremy Wildfire, MS, Cynthia M

Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban.

Influence of early-life exposures on food sensitization and food allergy in an inner-city birth cohort Emily C. McGowan, MD, Gordon R. Bloomberg, MD,

Development and cross-sectional validation of the Childhood Asthma Control Test Andrew H. Liu, MD, Robert Zeiger, MD, Christine Sorkness, PharmD, Todd.

Diagnosis and management of early asthma in preschool-aged children

Päivi M. Salo, PhD, Samuel J

House dust mite sublingual immunotherapy: Results of a US trial

A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children Felicia A. Rabito, PhD, MPH, John C. Carlson,

Suzanne Havstad, MA, Ganesa Wegienka, PhD, Edward M

Asthma control, adiposity, and adipokines among inner-city adolescents

One step forward, 2 steps back: The enigma of preschool wheeze

Asthma morbidity among inner-city adolescents receiving guidelines-based therapy: Role of predictors in the setting of high adherence Rebecca S. Gruchalla,

Acute respiratory health effects of air pollution on children with asthma in US inner cities George T. O'Connor, MD, MS, Lucas Neas, DSc, Benjamin Vaughn,

Martin Brasholt, MD, Florent Baty, PhD, Hans Bisgaard, MD, DMSci

Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responses Diane R. Gold, MD, MPH,

Jessica H. Savage, MD, MHS, Elizabeth C. Matsui, MD, MHS, Robert A

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis Elisabet Johansson, PhD, Jocelyn.

Caroline C. Horner, MD, MSCI, Courtney Dula, MS, Leonard B

Determinants of asthma after severe respiratory syncytial virus bronchiolitis Leonard B. Bacharier, MD, Rebecca Cohen, MD, Toni Schweiger, RN, Huiquing.

Negative affect, medication adherence, and asthma control in children

Safety and efficacy of repeated monthly carboplatin desensitization

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Eli O. Meltzer, MD, William W. Busse, MD, Sally E

Modeling asthma exacerbations through lung function in children

Stanley J. Szefler, MD, Brenda R. Phillips, MS, Fernando D

Development and validation of the Composite Asthma Severity Index—an outcome measure for use in children and adolescents Jeremy J. Wildfire, MS, Peter.

Presentation transcript:

Distinguishing characteristics of difficult-to-control asthma in inner-city children and adolescents Jacqueline A. Pongracic, MD, Rebecca Z. Krouse, MS, Denise C. Babineau, MS, PhD, Edward M. Zoratti, MD, Robyn T. Cohen, MD, MPH, Robert A. Wood, MD, Gurjit K. Khurana Hershey, MD, PhD, Carolyn M. Kercsmar, MD, Rebecca S. Gruchalla, MD, PhD, Meyer Kattan, MD, Stephen J. Teach, MD, MPH, Christine C. Johnson, PhD, MPH, Leonard B. Bacharier, MD, James E. Gern, MD, Steven M. Sigelman, RN, MHA, Peter J. Gergen, MD, MPH, Alkis Togias, MD, Cynthia M. Visness, PhD, William W. Busse, MD, Andrew H. Liu, MD Journal of Allergy and Clinical Immunology Volume 138, Issue 4, Pages 1030-1041 (October 2016) DOI: 10.1016/j.jaci.2016.06.059 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Journal of Allergy and Clinical Immunology 2016 138, 1030-1041DOI: (10 Journal of Allergy and Clinical Immunology 2016 138, 1030-1041DOI: (10.1016/j.jaci.2016.06.059) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Schematic of APIC study design: flow diagram illustrating (1) screening visit; (2) clinic visits; (3) definition of the easy-to-control, indeterminate, and difficult-to-control groups based on controller treatment step throughout the study; and (4) domains used to group characteristics measured on each participant throughout the study. Journal of Allergy and Clinical Immunology 2016 138, 1030-1041DOI: (10.1016/j.jaci.2016.06.059) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 CONSORT diagram: flow diagram illustrating the number of subjects screened, as well as the number of participants in the full APIC cohort and included in the analytic sample. Journal of Allergy and Clinical Immunology 2016 138, 1030-1041DOI: (10.1016/j.jaci.2016.06.059) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Controller treatment step for the easy-to-control and difficult-to-control groups over 12 months. Green and blue lines (shaded areas) indicate means (95% CIs) of controller treatment step for the easy-to-control and difficult-to-control groups, respectively, over 12 months. Journal of Allergy and Clinical Immunology 2016 138, 1030-1041DOI: (10.1016/j.jaci.2016.06.059) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Seasonal variation in clinical severity measures in the easy-to-control, indeterminate, and difficult-to-control groups. Green and blue lines (shaded areas) indicate means or probabilities (95% CIs) of clinical severity measures for the easy-to-control and difficult-to-control groups, respectively, over 12 months. Clinical severity measures are the Composite Asthma Severity Index (CASI) component measuring day symptoms and albuterol use in the last 2 weeks (0-3 points), the CASI component measuring nighttime symptoms and albuterol use in the last 2 weeks (0-3 points), the FEV1/FVC ratio (×100), and the monthly incidence of exacerbations, as defined by prednisone use. Journal of Allergy and Clinical Immunology 2016 138, 1030-1041DOI: (10.1016/j.jaci.2016.06.059) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Variable importance plot of characteristics (with and without pulmonary physiology variables) distinguishing the difficult-to-control from easy-to-control groups. Circles plot median z scores for each variable, a measure of importance obtained from Boruta, a feature selection algorithm in which higher values indicate a higher level of importance. Solid blue circles indicate variables confirmed as being relevant to distinguishing the difficult-to-control from easy-to-control groups. Pink and green circles indicate variables that are tentative or rejected, respectively, and are not relevant to distinguishing between the difficult-to-control from easy-to-control groups. Journal of Allergy and Clinical Immunology 2016 138, 1030-1041DOI: (10.1016/j.jaci.2016.06.059) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions