Robo3 in the GnRH neuronal system.

Slides:

Advertisements

Similar presentations

Fig. S1. Sequential retroviral and lentiviral transduction of GSCs and short term selection did not significantly affect their stem properties. A) Morphology.

Advertisements

Volume 9, Issue 5, Pages (November 2017)

by Cornelia Halin, Nadja E. Tobler, Benjamin Vigl, Lawrence F

Volume 59, Issue 3, Pages (August 2008)

Density of dendritic spines on L2/3 pyramidal neurons is greater in visual cortex of germline PirB−/− mice than in PirB+/+ mice at P30. Density of dendritic.

Increased astrocyte proliferation is paralleled with reduced infiltration of immune cells in mice with inducible SMOM2 expression in astrocytes at 5 dpi.

Fluorescence-stained images and respective bright-field images of mouse spleen tissue sections area investigated using Raman spectroscopy. Fluorescence-stained.

Smaller T cell zone FRC areas in aged spleens.

Growth Arrest Failure, G1 Restriction Point Override, and S Phase Death of Sensory Precursor Cells in the Absence of Neurotrophin-3 Wael M ElShamy, Lena.

Innervation of Wt1+ neurons and number of commissural neurons in neonatal mice. Innervation of Wt1+ neurons and number of commissural neurons in neonatal.

Isaac Perea-Gil et al. BTS 2016;1:

Cytotoxic therapy induces CSF1-dependent macrophage recruitment.

X-Chromosome Inactivation Patterns Are Unbalanced and Affect the Phenotypic Outcome in a Mouse Model of Rett Syndrome Juan I. Young, Huda Y. Zoghbi

Detection and tracking of individual SNAP-tagged proteins on the surface of living cells. Detection and tracking of individual SNAP-tagged proteins on.

BTB/POZ-Zinc Finger Protein Abrupt Suppresses Dendritic Branching in a Neuronal Subtype-Specific and Dosage-Dependent Manner Wenjun Li, Fay Wang, Laurent.

CD169+ macrophages mediate Lm translocation to the splenic T cell zones. CD169+ macrophages mediate Lm translocation to the splenic T cell zones. (A) Confocal.

Elysse C. Filipe et al. BTS 2018;3:38-53

TrkB-T1 is upregulated in cerebellum of Pex14ΔC/ΔC BL/ICR mouse at P3.

Volume 10, Issue 4, Pages (April 2018)

Atypical PKC and Notch Inhibition Differentially Modulate Cortical Interneuron Subclass Fate from Embryonic Stem Cells David J. Tischfield, Junho Kim,

Axonal swelling and impairment of dendritic development in Purkinje cells from Pex14ΔC/ΔC BL/ICR mouse upon treatment with BDNF. Axonal swelling and impairment.

BDNF expression in the cerebellum and brain stem region.

Impaired TrkB signaling in the cerebellum of Pex14ΔC/ΔC BL/ICR mice.

The EGFR Is Required for Proper Innervation to the Skin

Volume 9, Issue 8, Pages (April 1999)

Volume 13, Issue 12, Pages (December 2015)

Defect of cerebellar development and malformation of Purkinje cells in Pex14ΔC/ΔC BL/ICR mice. Defect of cerebellar development and malformation of Purkinje.

Neuronal ATM level is reduced in mouse models of AD

Commissural Wt1+ neurons.

ILK knockdown decreases mTOR signaling in PKD kidneys.

Tapetal mitochondria in wild-type (WT), drp3b, and elm1 mutants.

Up-regulation of BDNF induces the neurite outgrowth of SH-SY5Y cells.

Occurrence of prominin-1-containing particles in the ventricular fluid of the embryonic mouse brain. Occurrence of prominin-1-containing particles in the.

Fig. 3. Hts and Dlg are in a complex at the postsynaptic membrane of larval NMJs.(A–B″) PLA with HtsM and Dlg antibodies (green) performed on third instar.

Inflammation is associated with increased basal-cell plasticity in the Nkx3.1 mutant prostate. Inflammation is associated with increased basal-cell plasticity.

DHR3 suppresses Phm protein levels.

Quantitative evaluation of auxin-regulated PIN gene expression.

Oocyte polarity is disrupted in the presence of FP41 mutant PFCs

FAK/Src activity is required to trap PTP1BDA in adhesions.

Defects in neuronal cell migration from the SVZ

Postmitotic Prox1-deficient DG cells exhibit pyramidal cell morphology

Colocalisation and influence on migration.

Expression analysis of periostin in DRG

CD169+ macrophages mediate the transport of bacteria to T cell zones by trans-infecting CD8α+ DCs. CD169+ macrophages mediate the transport of bacteria.

Exo70 is recruited to the plasma membrane at sites of mechanical wounding. Exo70 is recruited to the plasma membrane at sites of mechanical wounding. NRK.

Lar function is not required for Stat92E accumulation in GSCs

Abnormal adherens junctions between hub cells and GSCs in Lar mutants.

Apc2 localization and centrosome orientation are altered in Lar mutant GSCs. (A-B′) Apc2 (white, A,B; red, A′,B′) localization in wild-type (A,A′) and.

Cell-autonomous migration of gata5/smarcd3b-expressing cells to the heart. Cell-autonomous migration of gata5/smarcd3b-expressing cells to the heart. (A-E)

Characterization of NEX-CRE mice and analysis of Itgb1 expression by flow cytometry. a–n , Z/EG reporter mice carrying a CRE-inducible GFP transgene were.

CENP-F staining in prometaphase and metaphase spermatocytes from B6 and Rb/+ mice. CENP-F staining in prometaphase and metaphase spermatocytes from B6.

Fig. 5. Testis defects in STK35 KO mice.

Oxidative stress is elevated in tumors grown in Fbln5−/− mice.

WT MARCH8, but not the CS mutant, specifically ubiquitinates and downregulates TfR. WT MARCH8, but not the CS mutant, specifically ubiquitinates and downregulates.

IL-27 induces expression of multiple IR by CD8+ T cells.

A subset of nNOS+ interneurons derive from the CGE and coexpresses VIP

c-Fos in RFMes GABAergic neurons across groups.

Neuronal and glial expression of Nogo-A and synaptic localization of Nogo-A and NgR 1 in the motor cortex. Neuronal and glial expression of Nogo-A and.

Co-expression of periostin and Sox10 in DRG and DRG explant cultures.

GFP is expressed selectively in NPY neurons.

Diaphanous regulates the presynaptic actin cytoskeleton.

Diaphanous is required presynaptically for normal synaptic growth.

Domain 3, comprising the basolateral calyx and the stretch of axon leading to the heminode, selectively expressed NaV channels, KCNQ3, and certain scaffolding.

Expression of p130CAS in primary culture neurons

Targeting β-actin and GAP-43 mRNAs into axons using the STAT3α 3′UTR selectively modulates axonal growth phenotypes. Targeting β-actin and GAP-43 mRNAs.

Fig. 2 IRF8 is expressed in CD68+ macrophages after SCI.

TAMs directly contribute to tumor hypoxia.

Passive immunization with CT α-syn antibodies improved TH pathology and neuroinflammation in the striatum of α-syn tg mice. Passive immunization with CT.

Snail-induced multinucleation follows midbody persistence.

Cofilin-GFP forms rods that sequester pMAP during ATP depletion.

Presentation transcript:

Robo3 in the GnRH neuronal system. Robo3 in the GnRH neuronal system. (A,B) Expression of Robo3 in GnRH neurons. (A) RT-PCR on FACS-sorted E14.5 GFP-GnRH neurons revealed the expression of Robo3 (229 bp). C+, positive control E14.5 mouse head; C–, negative control water. (B) Sagittal sections from E14 Robo3+/– animals were immunostained for GnRH and GFP. Colocalisation of GnRH (red) and Robo3 (green) is indicated (arrowheads and inset). (C-F) Robo3–/– mice have a reduced number of GnRH neurons in the FB. (C-D′) Sagittal sections of E14.5 mouse heads were immunolabelled for GnRH to reveal migrating neurons (arrowheads) in NC and FB. Higher magnification images are shown in C′,D′. There is a reduction of GnRH neurons in the FB of Robo3–/– mice (Δ in D′). (E,F) Counts of GnRH+ neurons in the head (E) and FB (F) of E14.5 wild-type and Robo3–/– mice revealed no differences in total number (E), but a statistically significant reduction in the FB of Robo3 mutants compared with wild-type littermates (F). (G-K) Chemomigratory response of GN11 cells towards Slit2. Representative images of migrated GN11 cells in a Boyden chamber assay with mock conditioned media of COS-7 cells (G) and Slit2-expressing COS-7 cells in the absence (H) or presence of Robo1/2 (I), Robo1-3 (J) or Robo3 (K) antibodies. (L) Counts of migrated GN11 cells/mm2 towards the indicated stimuli. Mean ± s.e.m. **P<0.01, ***P<0.001. Scale bars: 50 μm in B; 100 μm in C,D; 75 μm in C′,D′; 50 μm in G-K. Anna Cariboni et al. Development 2012;139:3326-3331 © 2012.