Novel Hairless RET-Transgenic Mouse Line with Melanocytic Nevi and Anagen Hair Follicles Masashi Kato, Kozue Takeda, Yoshiyuki Kawamoto, Toyonori Tsuzuki,

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Novel Hairless RET-Transgenic Mouse Line with Melanocytic Nevi and Anagen Hair Follicles Masashi Kato, Kozue Takeda, Yoshiyuki Kawamoto, Toyonori Tsuzuki, Yoko Kato, Tamio Ohno, Khaled Hossain, Imtiaz Iftakhar-E- Khuda, Nobutaka Ohgami, Ken-ichi Isobe, Masahide Takahashi, Izumi Nakashima Journal of Investigative Dermatology Volume 126, Issue 11, Pages 2547-2550 (November 2006) DOI: 10.1038/sj.jid.5700444 Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Macroscopic and microscopic characteristics of HL/RET-transgenic mice. Macroscopic (a, g) and microscopic (b–f, h) appearances of control skin (b, c), hyperpigmented skin (d, black arrowheads in e and f), congenital melanocytic nevus (white arrows in e and f), and benign tumor (white arrow in g and h) from a representative 12-week-old HL/RET-transgenic mouse of line 242-hr/hr (bottom mouse of a, d, e, f), a control 12-week-old hairless non-transgenic albino mouse (top mouse of a, b), a control 12-week-old hairless non-transgenic conventionally pigmented (non-albino) mouse (c), and an original haired 12-week-old RET-transgenic mouse of line 304/B6 (g, h) are presented. Tissues were stained with hematoxylin and eosin (b–e, h) or immunohistochemically with anti-S100 antibody (f). There were basically no differences between an albino non-transgenic hairless mouse and a pigmented hairless mouse in hair cycle (b, c) and macroscopic appearance (data not shown). The nevus was composed of S100-positive round or spindle-shaped cells with round nuclei and without a mitotic profile (e, f). Melanophages were also observed in the nevus (e, f). The benign tumor in the original RET-transgenic mice of line 304/B6 consisted of S-100-positive cells as reported previously (data not shown) (Iwamoto et al., 1991; Kato et al., 1998a, 1998b). Immunohistochemistry was performed by a previously reported method (Kato et al., 2004). Bar=100μm (b, c) and 200μm (d, e, f, h). Journal of Investigative Dermatology 2006 126, 2547-2550DOI: (10.1038/sj.jid.5700444) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions