Alterations in expression of endometrial endothelial nitric oxide synthase and αvβ3 integrin in women with endometriosis Omid Khorram, M.D., Ph.D., Bruce.

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Presentation transcript:

Alterations in expression of endometrial endothelial nitric oxide synthase and αvβ3 integrin in women with endometriosis Omid Khorram, M.D., Ph.D., Bruce A Lessey, M.D., Ph.D. Fertility and Sterility Volume 78, Issue 4, Pages 860-864 (October 2002) DOI: 10.1016/S0015-0282(02)03347-2

FIGURE 1 Immunohistochemical localization of αvβ3 integrin and eNOS in the human endometrium. The left panel is a negative control from a patient without endometriosis (top) and a patient with endometriosis (bottom). The middle panel shows αvβ3 integrin staining pattern in a fertile control (top) and a patient with endometriosis (bottom). The right panel shows endothelial nitric oxide synthase staining in a fertile control (top) and a patient with endometriosis (bottom). Both proteins were predominantly localized in the glandular and luminal epithelium. The patient with endometriosis showed more intense eNOS staining and less αvβ3 integrin staining compared with the fertile control. Khorram. Expression of eNOS and αvβ3 integrin in endometriosis. Fertil Steril 2002. Fertility and Sterility 2002 78, 860-864DOI: (10.1016/S0015-0282(02)03347-2)

FIGURE 2 Endothelial nitric oxide synthase (eNOS) HSCORE shown for glandular epithelium (top), stroma (middle), and luminal epithelium (bottom) in controls and patients with endometriosis. ∗∗∗P<.001 compared with controls. Khorram. Expression of eNOS and αvβ3 integrin in endometriosis. Fertil Steril 2002. Fertility and Sterility 2002 78, 860-864DOI: (10.1016/S0015-0282(02)03347-2)

FIGURE 3 The αvβ3 integrin HSCORE in glandular epithelium (top), stroma (middle), and luminal epithelium (bottom) in controls and patients with endometriosis. ∗P<.05, ∗∗∗P<.001 compared with patients with endometriosis. Khorram. Expression of eNOS and αvβ3 integrin in endometriosis. Fertil Steril 2002. Fertility and Sterility 2002 78, 860-864DOI: (10.1016/S0015-0282(02)03347-2)

FIGURE 4 A proposed model showing the involvement of the nitric oxide (NO) pathway in the pathogenesis of endometriosis and infertility associated with this condition. COX2 = cyclooxygenase-2; eNOS = endothelial nitric oxide synthase; IL = interleukin; PGE2 = prostaglandin E2; RANTES = regulated upon activation normal T-cell expressed and secreted. Khorram. Expression of eNOS and αvβ3 integrin in endometriosis. Fertil Steril 2002. Fertility and Sterility 2002 78, 860-864DOI: (10.1016/S0015-0282(02)03347-2)