Platelet survival and serotonin content after placement of arterial prostheses in dogs: Effects of neointimal coverage and high- and low-dose aspirin

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Presentation transcript:

Platelet survival and serotonin content after placement of arterial prostheses in dogs: Effects of neointimal coverage and high- and low-dose aspirin G.Patrick Clagett, M.D., Howard Hufnagel, B.S., Michael T. Watkins, M.D., John B. Sharefkin, M.D. Journal of Vascular Surgery Volume 6, Issue 6, Pages 555-562 (December 1987) DOI: 10.1016/0741-5214(87)90270-9 Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 1 Changes in platelet survival with different aspirin doses (0, 2, and 30 mg/kg) before and 6 to 8 weeks and 28 to 32 weeks after placement of aortic prostheses. Significant interaction (p < 0.05, indicated by asterisk) on the basis of aspirin dosage was seen in both postoperative time periods. No significant interaction was noted preoperatively. Journal of Vascular Surgery 1987 6, 555-562DOI: (10.1016/0741-5214(87)90270-9) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 2 Changes in platelet 5HT levels with different aspirin doses before and 6 to 8 weeks and 28 to 32 weeks after placement of aortic prostheses. Significant interaction (p < 0.05, indicated by asterisk) on the basis of aspirin dosage was seen 28 to 32 weeks postoperatively. Journal of Vascular Surgery 1987 6, 555-562DOI: (10.1016/0741-5214(87)90270-9) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions