Factors affecting standardization of rodent impact TBI models.

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Factors affecting standardization of rodent impact TBI models. Factors affecting standardization of rodent impact TBI models. TBI outcomes depend on the head response to mechanical input, surgery and anesthesia, and the age, gender and genotype of animal. Head response is controlled by the input energy, head and body support (which affect movement during impact), and skull properties. The figure summarizes interactions between these experimental variables. Dhananjay R. Namjoshi et al. Dis. Model. Mech. 2013;6:1325-1338 © 2013. Published by The Company of Biologists Ltd