Helicobacter species induce pTreg cell differentiation during homeostasis. Helicobacter species induce pTreg cell differentiation during homeostasis. (A)

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Volume 17, Issue 1, Pages (September 2016)

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Helicobacter species induce pTreg cell differentiation during homeostasis. Helicobacter species induce pTreg cell differentiation during homeostasis. (A)

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Colonic Treg TCRs react to MA Helicobacter species.

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Helicobacter species induce pTreg cell differentiation during homeostasis. Helicobacter species induce pTreg cell differentiation during homeostasis. (A) In vivo validation of TCR reactivity to Helicobacter species. Three-week-old SPF mice were treated with ampicillin (amp) for 2 weeks via drinking water. Two days after the last treatment, H. typhlonius or H. apodemus were gavaged for a total of three times every other day. With the last gavage, congenically marked naïve CT2/CT6 Tg cells or retrovirally expressed CT9/T7-1 cells were transferred. Seven days after transfer, cLP cells were analyzed by flow cytometry for (top) the development of Treg (Foxp3+) cells (P = 0.000003, P = 0.001, P = 0.0002, P = 0.0046, Student’s t test; n = 4 and 5 for CT2, 6 and 7 for CT9, 5 for T7-1, and 3 and 5 for CT6), (middle) frequency of transferred TCR-expressing cells among the host CD4+ T cells (P = 0.0442, P = 0.021, P = 0.0046, P = 0.0705, Student’s t test; n = 4 and 5 for CT2, 6 and 7 for CT9, 5 for T7-1, and 3 and 5 for CT6), or (bottom) CTV dilution (P = 0.00000002, P = 0.0000007, Student’s t test; n = 4 and 5 for CT2 and 3 and 5 for CT6). (B) T cell response to Helicobacter in vivo is species-specific. Three-week-old SPF mice obtained from Charles River Laboratories were gavaged with H. typhlonius or H. apodemus (for a total of three times every other day). With the last gavage, congenically marked naïve CT2 and CT6 Tg cells (105 each) were cotransferred. One week after transfer, cells from the distal mesenteric lymph node (dMLN) were analyzed by flow cytometry for the frequency of transferred TCR-expressing cells among the host CD4+ T cells (left), CTV dilution (middle), or development of Treg (Foxp3+) cells (right) (n = 4, 6, and 6). Bars indicate mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Jiani N. Chai et al. Sci. Immunol. 2017;2:eaal5068 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works