Influence of extracellular pH on intracellular pH in arterioles and skeletal muscle of spontaneously hypertensive and Wistar-Kyoto rats Pauline Wimberger,

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Influence of extracellular pH on intracellular pH in arterioles and skeletal muscle of spontaneously hypertensive and Wistar-Kyoto rats Pauline Wimberger, Marcos Marin-Grez Kidney International Volume 54, Pages S180-S182 (September 1998) DOI: 10.1046/j.1523-1755.1998.06740.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Intracellular pH (pHi) regulation in mesenteric arterioles from spontaneously hypertensive (SHR; ○; N = 10) and Wistar-Kyoto (WKY; •; N = 10) rats and the effect of 50-μM 5-(N-ethylisopropyl)amiloride on mesenteric arterioles from SHR (EIPA; ▵; N = 6).Extracellular pH (pHo) was varied by superfusion with N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid (HEPES)-buffered saline solution. Kidney International 1998 54, S180-S182DOI: (10.1046/j.1523-1755.1998.06740.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Proton efflux rate from mesenteric arterioles from spontaneously hypertensive (SHR; open symbols ○ body wt 179 ± 4 g) and Wistar-Kyoto (WKY; solid symbols •, body wt 249 ± 1 g) rats as a function of extracellular [Na] ([Na]o). Proton efflux is calculated as the product of the rate of change of pHi (pH/min) and the cell's buffering capacity (mm/pH), and thus has units of mM per min (inset: Lineweaver-Burk plot). Kidney International 1998 54, S180-S182DOI: (10.1046/j.1523-1755.1998.06740.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Proton efflux from mesenteric arterioles following a 140-mM change in [Na]o as a function of pHi in young (dash-dot line) and old (solid line) Wistar-Kyoto (WKY) and young (dotted line) and old (dashed line) spontaneously hypertensive (SHR). Inset: time course of the change in pHi following the change in [Na]o. Kidney International 1998 54, S180-S182DOI: (10.1046/j.1523-1755.1998.06740.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, S180-S182DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, S180-S182DOI: (10.1046/j.1523-1755.1998.06740.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, S180-S182DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, S180-S182DOI: (10.1046/j.1523-1755.1998.06740.x) Copyright © 1998 International Society of Nephrology Terms and Conditions