Chimeric HA-based universal influenza virus vaccine concept.

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Chimeric HA-based universal influenza virus vaccine concept. Chimeric HA-based universal influenza virus vaccine concept. (A) Humans are repeatedly exposed to circulating H1N1 influenza viruses by infection or vaccination. Such repeated exposure induces Abs against the immunodominant HA head domain. (B) By using chimeric influenza Ags sharing the same H1 stalk but different HA head domains (pictured in blue and pink), the immune response can be redirected toward the otherwise immuno-subdominant HA stalk epitopes. The immunosilencing of the HA head also allows redirecting of the immune response to other immuno-subdominant domains of the virus (including the NA; not shown here). Angela Choi et al. ImmunoHorizons 2019;3:133-148 Copyright © 2019 The Authors