Effects of LMHFV and oestrogen (E2) supplementation on bone healing in OVX mice 21 days after osteotomy. Effects of LMHFV and oestrogen (E2) supplementation.

Slides:

Advertisements

Similar presentations

Volume 47, Issue 2, Pages (August 2010)

Advertisements

Volume 45, Issue 3, Pages (March 2014)

Date of download: 10/21/2017 Copyright © ASME. All rights reserved.

MR1-TM inhibits the development of severe ATD and pSS in CD28−/− NOD

Osteosarcoma histology.

Ocular defects produced by Daam1 mutation and in combination with diabetes. Ocular defects produced by Daam1 mutation and in combination with diabetes.

Type 1 immunity drives metabolic disease but protects against NAFLD

The pathophysiological processes linked to kidney disease.

Morphological alterations in pancreatic islets demonstrate a compensatory response to HFHC diet and STZ-induced β-cell loss. Morphological alterations.

Effects of KY‐02327 on OVX‐induced osteoporosis model mice

Representative flow cytometric analysis of bone marrow, spleen and whole blood from EpoWT/WT, EpoΔ/Δ and EpoWT/Δ mice. Representative flow cytometric analysis.

Azithromycin treatment eliminates NTHi infection.

Representative illustrations of a sagittal lung section stained with H&E in a control and a CS-exposed mouse after 6 months. Representative illustrations.

Total and differential cell counting in the broncho-alveolar lavage of mice exposed to CS or air during 3 or 6 months. Total and differential cell counting.

Alterations in Notch signaling affect the frequency of intermediate and main IHBD branches. Alterations in Notch signaling affect the frequency of intermediate.

MicroCT analysis reveals that IHBD average volume is modulated with age upon deletion of RBP-J or activation of Notch1. MicroCT analysis reveals that IHBD.

Tomoregulin-1 improves cardiac pathological changes after pressure overload. Tomoregulin-1 improves cardiac pathological changes after pressure overload.

Discordance and similarity between humans with FA and FA mouse models.

Molecular profiles of lung, and of blood and plasma in M

Inflammation is associated with increased basal-cell plasticity in the Nkx3.1 mutant prostate. Inflammation is associated with increased basal-cell plasticity.

Crotonate increases histone crotonylation in mouse kidney.

Erythroid progenitor capacity of Epo transgenic mice.

Enterocytes fail to migrate consistently towards the villus tip in live APCMin/+ tissue. Enterocytes fail to migrate consistently towards the villus tip.

Expression of tomoregulin-1 in wild-type and cardiac hypertrophy mouse myocardium. Expression of tomoregulin-1 in wild-type and cardiac hypertrophy mouse.

Challenge with oxazolone results in epithelial hyperplasia and influx of inflammatory cells into the epidermis and dermis and keratosis as observed in.

Characterization of Col1a1FRT-STOP-FRT-Cre-ER-T2 mice.

Secondary storage of GM2 ganglioside and cholesterol in Fuca1-deficient mice. Secondary storage of GM2 ganglioside and cholesterol in Fuca1-deficient mice.

Obesity affected the metabolic response to stroke.

Formation of papilloma lesions in the UroIICre+Fgfr3+/K644EK-RasG12D/+ model. Formation of papilloma lesions in theUroIICre+Fgfr3+/K644EK-RasG12D/+model.

Expression data confirm and extend existing knowledge

Increased osteoclastogenesis in the mandibular bone of Fgfr2+/S252W embryos at E16.5. Increased osteoclastogenesis in the mandibular bone of Fgfr2+/S252W.

Kmt2b is required for SSC-to-progenitor transition.

Tamoxifen injections induce DNA damage response signaling in αMHC-MerCreMer mice.αMHC-MerCreMer+/+ mice received an injection of 60 μg/g body weight of.

Tamoxifen injections in αMHC-MerCreMer mice induce a loxP-independent DNA damage response, leading to myocardial dysfunction and death. Tamoxifen injections.

Detection of nuclear foci by FISH on frozen sections of diaphragm muscle prepared from 2-month-old DMSXL mice. Detection of nuclear foci by FISH on frozen.

Elevated expression of vegfaa in hemangiosarcoma.

Fig. 6. STK35 KO mice show ovary defects.

The mutants exhibit congenital hypothyroidism.

Distribution and extent of expression.

Comparison ofMyc-induced zebrafish liver tumors with different stages of human HCC and seven mouse HCC models. Comparison ofMyc-induced zebrafish liver.

Relationship between FFM, daily EI and daily profile of hunger.

Chemical chaperone 4-PBA rescues the hi559 GI phenotype.

The genomic distribution of essential and non-essential mouse genes, separated into known and predicted essentiality. The genomic distribution of essential.

Characterization of zebrafish muscle wasting in krasG12V-induced HCC zebrafish. 4-month-old male adult krasG12V and WT zebrafish were treated with dox.

Elevation of ERK downstream signaling is associated with tumor formation in the bladder and in papilloma formation. Elevation of ERK downstream signaling.

2DG downregulates the expression of HIF-1α, PDK1 and c-Myc in NB xenograft. 2DG downregulates the expression of HIF-1α, PDK1 and c-Myc in NB xenograft.

Rgs16::GFP expression in pancreatic neoplasia.

Impaired elastogenesis in Ltbp4S−/−;Fibulin-4R/R mice with reduced interaction of Ltbp-4L and fibulin-4. Impaired elastogenesis in Ltbp4S−/−;Fibulin-4R/R.

Otitis media in Edaraddswh/swh rats is associated with smaller auditory-tube submucosal glands (SMGs). Otitis media in Edaraddswh/swh rats is associated.

Homozygous col22a1−/− embryos show increased percentage of hemorrhages when raised at increased temperature. Homozygous col22a1−/− embryos show increased.

Induction of liver tumors in TO(Myc) fish.

Tumor location determines response to intravenous FOLFIRINOX chemotherapy. Tumor location determines response to intravenous FOLFIRINOX chemotherapy. (A)

Effect of Dipy on the expression of chondrogenic markers.

Nerve conduction slowing and DRG sensory neuron and nuclear atrophy in 16-week-old diabetic mice. Nerve conduction slowing and DRG sensory neuron and nuclear.

Deletion of Sox2 in adult mice inhibits incisor regeneration.

MMP-9 expression. MMP-9 expression. (A) Lungs from M. tuberculosis-infected (H37Rv, 14 wpi, untreated) and age-matched uninfected (control) mice were harvested.

Histological analyses for limb-specific Uhrf1 KO mice.

Association of MMP expression with macrophages.

miR-145 overexpression reduces IGF1-coated bead attachment.

HFHC/STZ guinea pigs develop insulin-independent diabetes that is responsive to oral antihyperglycemic therapy. HFHC/STZ guinea pigs develop insulin-independent.

Peroxisome speeds were slower in patient and control cells.

Accelerated retinal degeneration after systemic depletion of circulating BM-derived microglia in rd7/rd7;Tg/Tg mice. Accelerated retinal degeneration after.

Fig. 5. Testis defects in STK35 KO mice.

Histology of Brucella bone marrow foci in mice.

Effects of paclitaxel and vinblastine.

Stages of notochord transformation into the NP in the mouse embryo.

MMP expression at the growth plate.

Lack of Ctip2 is associated with impaired proliferation and delayed onset of differentiation during early stages of epidermal development. Lack of Ctip2.

2DG suppresses of lamellipodia and filopodia and causes disorganization of F-actin filaments in murine endothelial cells. 2DG suppresses of lamellipodia.

Upon challenge with oxazolone, human leukocytes (mainly consisting of T cells) infiltrate the dermis and epidermis. Upon challenge with oxazolone, human.

Presentation transcript:

Effects of LMHFV and oestrogen (E2) supplementation on bone healing in OVX mice 21 days after osteotomy. Effects of LMHFV and oestrogen (E2) supplementation on bone healing in OVX mice 21 days after osteotomy. The dotted lines indicate the values of aged-matched non-OVX mice. E2 supplementation of OVX mice significantly improved fracture healing. Additional LMHFV did not further increase bone healing. Physiological values of aged-matched non-OVX mice were not achieved. (A) Flexural rigidity (EI) of the fracture callus after 21 days. (B) Total callus volume (TV) as assessed by μCT. (C) Bone volume/total volume (BV/TV) assessed using μCT. (D) Callus composition on day 10 assessed by histomorphometry, given as a percentage of the total callus area. Bone, TOT; cartilage, Cg; and fibrous tissue, FT. (E) Callus composition on day 21 as assessed by histomorphometry. (F) Percentage of mice with bony bridging of the fracture gap. (G–I) Representative histological sections of fractured femurs 21 days after osteotomy stained using Giemsa. (G) non-vibrated OVX mouse, (H) non-vibrated OVX mouse with E2 supplementation, (I) vibrated OVX mouse with E2 supplementation. Scale bars: 500 μm. *P<0.05. n=8. Esther Wehrle et al. Dis. Model. Mech. 2015;8:93-104 © 2015. Published by The Company of Biologists Ltd