Connective tissue cells, but not myogenic cells, obey the rule of distal transformation in axolotl limb regeneration. Connective tissue cells, but not.

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Connective tissue cells, but not myogenic cells, obey the rule of distal transformation in axolotl limb regeneration. Connective tissue cells, but not myogenic cells, obey the rule of distal transformation in axolotl limb regeneration. (A) Schema of wrist blastema transplantation from an animal that expresses GFP in muscle fibres (green) onto a non-transgenic upper arm (UA) stump. (B) Experimental result of A: upon regeneration, GFP-muscle fibres (green) are found in the UA, lower arm (LA) and hand. (C,D) Upon wrist blastema transplantation from a GFP-CT animal, in which connective tissue cells express GFP, onto a non-transgenic UA stump, GFP+ connective tissue cells are found only in the hand of the regenerate. (E,F) UA blastema transplantation from a GFP-CT animal onto a non-transgenic UA stump results in GFP-connective tissues cells in UA, LA and hand of the regenerate. Dashed lines in B,D,F outline the limb. Scale bars: 2 mm. Eugen Nacu et al. Development 2013;140:513-518 © 2013. Published by The Company of Biologists Ltd