IFN-γ–producing cells in the spleen and lungs postimmunization.

Slides:

Advertisements

Similar presentations

Fig. 1. Level of Mac-1 expression on naive and recently activated LCMV GP33–41-specific T cells from TCR 318 transgenic mice. (A and B) Splenocytes from.

Advertisements

Volume 56, Issue 1, Pages (July 2009)

Serum IgG (A–D) and IgA (E–H) titer from BALB/c mice (n = 5/group) at day 0 or following COBRA P1 virus i.n., i.p., or i.m. prime at day 21 or following.

Volume 8, Issue 2, Pages (February 1998)

Volume 11, Issue 12, Pages (June 2015)

Mean and difference Raman spectra of T cells isolated from spleen of sham mice and endotoxemic mice for time points 1, 4, 10, and 30 d. Mean and difference.

Anti–4-1BB/PD-1 combination enhanced antigen-specific T-cell response.

DKO CD8+ T cells demonstrate a strong effector response but altered memory differentiation and maintenance after LCMV infection. DKO CD8+ T cells demonstrate.

CCL21 localizes to T cell zone FRCs in young and aged spleens.

MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific T-bet+ population. MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific.

Prf1−/− mice exhibit increased immunopathology with prior CD8 T cell memory secondary to immunization. Prf1−/− mice exhibit increased immunopathology with.

Enhanced proliferation and cytokine production in DGKζ and Cbl-b deficient mice. Enhanced proliferation and cytokine production in DGKζ and Cbl-b deficient.

Volume 6, Issue 5, Pages (May 1997)

CD169+ macrophages play a critical role in mediating innate immune cell reorganization. CD169+ macrophages play a critical role in mediating innate immune.

Viperin−/−mice have an increased IFNγ Th1 response.

Confirmation of novel RSV CD8+ T cell epitopes.

STAT3 regulates IgE class switching in a Th2-type response.

Volume 21, Issue 9, Pages (November 2017)

Fig. 8 Combining M7824 with radiation or chemotherapy enhances antitumor efficacy. Combining M7824 with radiation or chemotherapy enhances antitumor efficacy.

Volume 13, Issue 2, Pages (February 2006)

RSV peptide library screen for candidate CD4+ T cell epitopes.

Human PBMC-derived MERS-CoV–specific T cells are multifunctional.

Eric A Butz, Michael J Bevan Immunity

Volume 13, Issue 4, Pages (April 2006)

Virus-specific T cell responses are detected in all MERS survivors.

CD44 Regulates Survival and Memory Development in Th1 Cells

Fig. 5 Treatment with an OX40 agonist antibody of 3-week-old HBVtgRag−/− mice or mice with chronic HBV disease results in an altered immune response to.

Volume 15, Issue 3, Pages (March 2014)

Serial vaccination with 32Dp210-derived whole cell vaccines in non-tumor-bearing mice stimulates robust antileukemic cytolytic activity. Serial vaccination.

PD-1–PD-L1 axis is highly expressed and is not IFNγ-dependent in a subcutaneous murine model of PDA. A, experimental design for establishment of subcutaneous.

CD8+ T cells were immunomodulated and required for the efficacy of anti–4-1BB/anti–PD-1 combination treatment. CD8+ T cells were immunomodulated and required.

Ag 85A–specific immune responses.

AN12855 is efficacious in acute and chronic murine models of TB infection. AN12855 is efficacious in acute and chronic murine models of TB infection. (A,

T-bethi MP cells produce IFN-γ in response to IL-12.

Fig. 6 In utero injection of inflammatory cytokines or adoptive transfer of activated T cells leads to pregnancy loss. In utero injection of inflammatory.

Figure 4 Increased susceptibility of MIF−/− CD4+ T cells to immunosuppression by Dex in EAE (A) MOG35-55 peptide-activated donor cells from wild-type (Wt)

Experimental design for serological analyses.

Chimeric HA-based universal influenza virus vaccine concept.

NKTfh cell–driven class switch against polysaccharide Ag is IL-21-influenced. NKTfh cell–driven class switch against polysaccharide Ag is IL-21-influenced.

IRF4 expression is modulated by the signaling of IL-2 family cytokines

CXCR5+/+ TFH cells are essential for the generation of LCMV-neutralizing antibodies and clearance of a persistent LCMV infection. CXCR5+/+ TFH cells are.

Antigen-specific immune responses are enhanced in hypertension.

Fig. 8 Combining M7824 with radiation or chemotherapy enhances antitumor efficacy. Combining M7824 with radiation or chemotherapy enhances antitumor efficacy.

NOD.hCD205 mice are susceptible to T1D.

Schematic representation of the immunization regimens used in this study. Schematic representation of the immunization regimens used in this study. BALB/c.

LG NK cells appear to be conventional in phenotype.

Prime and boosts with PBK001 vaccine provided 100% protection with low bacterial burden in organs. Prime and boosts with PBK001 vaccine provided 100% protection.

CD8 T cell memory alters the immune profile in enhanced HLH without altering viral load. CD8 T cell memory alters the immune profile in enhanced HLH without.

Figure 2 Effect of Dex on cytokine production by MIF−/− or Wt T cells in EAE Wild-type (Wt) and macrophage migration inhibitory factor (MIF)−/− mice were.

BMS blocks functional responses in primary immune cells driven by IFNα

CD11c+ DCs from NOD.hCD205 mice are able to process and present Ag to diabetogenic CD8+ T cells. CD11c+ DCs from NOD.hCD205 mice are able to process and.

Specific recognition of HOM-MEL-40/SSX2-derived p pulsed targets by p stimulated T-cells from patients with HOM-MEL-40/SSX2 positive breast.

Mice immunized twice with RRBC showed superior protection to tumor challenge with αGal-positive MC38 colon carcinoma cells compared with mock-immunized.

Natural processing and presentation of the HOM-MEL-40/SSX2-derived p peptide. Natural processing and presentation of the HOM-MEL-40/SSX2-derived.

Specificity of HOM-MEL-40/SSX2 p stimulated CD8+ T-cells.

Effects of AG on the colon histology score in the acute DSS colitis model. Effects of AG on the colon histology score in the acute DSS colitis model. Ten.

Augmentation of in vivo CMS5mHE tumor eradication by HER216-30, but not OVA Augmentation of in vivo CMS5mHE tumor eradication by HER216-30, but.

Primary B16F10 tumor inhibits experimental metastasis formation in the lung. Primary B16F10 tumor inhibits experimental metastasis formation in the lung.

Immunization regimens that include a GLA-SE-formulated protein vaccine generate memory CD4 T cells. Immunization regimens that include a GLA-SE-formulated.

Experimental metastasis inhibition by primary tumors is mediated by NK cells and IFNγ. Experimental metastasis inhibition by primary tumors is mediated.

HLA-A*0201 restriction of SSX2-derived p stimulated CD8+ T-cells.

Dual blockade of PD-1 and CTLA-4 directly activates CD4+Foxp3− cells in the absence of CD8+ or CD4+Foxp3+ cells. Dual blockade of PD-1 and CTLA-4 directly.

Tregs preferentially regulate TH2 cytokines in skin.

Reconstitution of the wild-type CD11b+Ly6G+ myeloid cell subset in Tgfbr2MyeKO mice reversed the diminished metastasis phenotype. Reconstitution of the.

Immune checkpoint molecule expression in primary and secondary tumors following radiotherapy. Immune checkpoint molecule expression in primary and secondary.

LSECtin, expressed by B16 cells, inhibits the tumor-specific immune responses both in vivo and in vitro. LSECtin, expressed by B16 cells, inhibits the.

Fig. 7 BEL immune response.

Memory phenotypes PBMC-derived MERS-CoV-specific T cells from CWs

Fig. 5 Effector function of MIH5 isotype variants.

Design and operation of p.DOM-epitope vaccines.

Presentation transcript:

IFN-γ–producing cells in the spleen and lungs postimmunization. IFN-γ–producing cells in the spleen and lungs postimmunization. After priming with QIV, C57BL/6 mice were immunized with different formulations, as described in Fig. 7, and the spleens and lungs of the animals were collected on day 66 to quantify the Ag-specific T cells in these organs. The cells isolated from the spleen (A–C) or the lungs (D–F) were stimulated with either the NP-derived peptide ASNENMETM (NP specific) (A and D), whole virus H1N1pdm09 (B and E), or the irrelevant peptide RAHYNIVTF (derived from human papillomavirus E7) (C and F), and the number of IFN-γ–producing cells was measured by ELISPOT. **p < 0.01, ***p < 0.001, ****p < 0.0001. Angela Choi et al. ImmunoHorizons 2019;3:133-148 Copyright © 2019 The Authors