INT-747 treatment showed antifibrotic, anti-inflammatory, and antioxidative effects on diabetic DBA/2J mice. INT-747 treatment showed antifibrotic, anti-inflammatory,

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INT-747 treatment showed antifibrotic, anti-inflammatory, and antioxidative effects on diabetic DBA/2J mice. INT-747 treatment showed antifibrotic, anti-inflammatory, and antioxidative effects on diabetic DBA/2J mice. A: Renal TGF-β1 mRNA expression determined by quantitative real-time PCR. B: Immunofluorescence staining of kidney sections for fibronectin. The expression level of fibronectin was normalized to that in the control group. C: Expression of α-SMA in kidney determined by quantitative real-time PCR and immunohistologic staining. FSP-1 mRNA expression in kidney was determined by quantitative real-time PCR. D: Immunofluorescence staining of kidney sections for synaptopodin (red) and CD68 (green). E: Renal NF-κB p65 subunit mRNA expression by quantitative real-time PCR and NF-κB activation determined by DNA binding assay. F: Nox-2 and p22-phox mRNA expression in kidney determined by quantitative real-time PCR. Oxidative carbonylation of proteins in kidney homogenate was measured by ELISA. *P < 0.05 vs. CON; **P < 0.05 vs. STZ (n = 6 mice per group). (A high-quality digital representation of this figure is available in the online issue.)‏ Xiaoxin X. Wang et al. Diabetes 2010;59:2916-2927 ©2010 by American Diabetes Association