Silencing of Keap1 reduced the expression of inflammatory markers in ConA-injected livers. Silencing of Keap1 reduced the expression of inflammatory markers.

Slides:

Advertisements

Similar presentations

Effect of miR-29a inhibition on miRNA and SCD expression in GIFT

Advertisements

Induction of mPer1 mRNA expression by prostaglandin E2 (PGE2) in NIH3T3 cells. Induction of mPer1 mRNA expression by prostaglandin E2 (PGE2) in NIH3T3.

SESN2 expression in lungs from healthy donors, habitual smokers without COPD and individuals with late-stage COPD. (A) Representative western blots of.

Bernard et al, Supplementary Figure S1

Acetylation of histone 3 in MEF2C and GATA4 loci is enhanced in differentiating 22q11.2DS hiPSCs. Acetylation of histone 3 in MEF2C and GATA4 loci is enhanced.

Azithromycin treatment eliminates NTHi infection.

BTN1 mRNA level in response to extracellular pH determined by comparative RT2PCR. BTN1mRNA level in response to extracellular pH determined by comparative.

Differential Cre-ERT activity and PTEN deletion in endometrial epithelial and stromal compartments. Differential Cre-ERT activity and PTEN deletion in.

Total and differential cell counting in the broncho-alveolar lavage of mice exposed to CS or air during 3 or 6 months. Total and differential cell counting.

Altered palate and jaw morphology in LgDel mice.

Tomoregulin-1 improves cardiac pathological changes after pressure overload. Tomoregulin-1 improves cardiac pathological changes after pressure overload.

Crotonate prevents downregulation of kidney PGC-1α and SIRT3 as well as causing CCL2 upregulation in experimental AKI. AKI was induced by a folic acid.

Crotonate increases histone crotonylation in mouse kidney.

Effect of OLHHA on the protein expression of relevant enzymes and factors related to lipid metabolism in the liver of obese Zucker rats. Effect of OLHHA.

Ingenuity pathway analysis of the genes enriched in both 96-h-induced MMs and human ccRCC. Ingenuity pathway analysis of the genes enriched in both 96-h-induced.

Expression of tomoregulin-1 in wild-type and cardiac hypertrophy mouse myocardium. Expression of tomoregulin-1 in wild-type and cardiac hypertrophy mouse.

The trafficking of VSVG–GFP to pre‐Golgi structures is impaired by depletion of GMAP‐210.The trafficking of VSVG–GFP to pre‐Golgi structures is impaired.

Pie charts showing the percentage of genes for selected enriched biological functions and pathways at different time points after hyperthermic seizures.

Identification of paracrine factors produced by satellite cells after exposure to matrix and necrotic cell debris for 24 hours. Identification of paracrine.

Challenge with oxazolone results in epithelial hyperplasia and influx of inflammatory cells into the epidermis and dermis and keratosis as observed in.

Fig. 7. SCF and IGF-1 accelerate fetal spleen erythropoiesis in vivo.

TWEAK downregulates SIRT3 in cultured tubular cells and this is prevented by crotonate. TWEAK downregulates SIRT3 in cultured tubular cells and this is.

Fig. 3. Characterization of unclassified cells (UCs).

Behavioral test parameters.

Obesity affected the metabolic response to stroke.

Effects of tumour size on response to treatment in the KPC model.

Fig. 3. Coilin levels correlate with altered nascent U2 snRNA, hTR and rRNA levels.RNA isolated from HeLa or WI-38 cells following RNAi targeting coilin.

Expression data confirm and extend existing knowledge

Factors affecting standardization of rodent impact TBI models.

Combined treatment with LY and sunitinib rescued hypervascularization.

Effects of ICER deficiency on MB-cAMP-induced activation of PKA-CREB-VEGF signaling and angiogenesis. Effects of ICER deficiency on MB-cAMP-induced activation.

Treatment of HCMT-CMs with bisoprolol.

Superimposed traces representing the effects of different concentrations of adrenaline on AP characteristics. Superimposed traces representing the effects.

Tamoxifen injections induce DNA damage response signaling in αMHC-MerCreMer mice.αMHC-MerCreMer+/+ mice received an injection of 60 μg/g body weight of.

Tamoxifen injections in αMHC-MerCreMer mice induce a loxP-independent DNA damage response, leading to myocardial dysfunction and death. Tamoxifen injections.

Elevated expression of vegfaa in hemangiosarcoma.

Loss of serotonergic markers after Smed-pitx RNAi is not due to stem cell-based turnover. Loss of serotonergic markers after Smed-pitx RNAi is not due.

The effect of TDP-43A315T expression on dendrite spine development.

Distribution and extent of expression.

Intestinal CAV1 deletion alters circulating FFAs but not TGs

P3/QBP1 co-treatment suppressed expanded-CAG-RNA-induced RNA toxicity and expanded-polyQ-protein-induced protein toxicity in vivo. P3/QBP1 co-treatment.

Functional classification and visualization of differentially expressed genes. Functional classification and visualization of differentially expressed.

Fig. 4. Quantitative mRNA expression of two membrane-bound trehalase genes in Harmonia axyridis in response to starvation (0–72 h). Quantitative mRNA expression.

TWEAK increases histone crotonylation in kidney tubular cells.

Elevation of ERK downstream signaling is associated with tumor formation in the bladder and in papilloma formation. Elevation of ERK downstream signaling.

Chronic phenytoin increases activity levels in Mecp2Null/Y mice.

2DG downregulates the expression of HIF-1α, PDK1 and c-Myc in NB xenograft. 2DG downregulates the expression of HIF-1α, PDK1 and c-Myc in NB xenograft.

Ang-1, ESE-1 and Tie-2 expression levels during teratogen-induced CDH

Expression of transgenic IGF-1Ea propeptide in the skin increases local Treg cell numbers. Expression of transgenic IGF-1Ea propeptide in the skin increases.

Tissue ATP levels measured in the liver, muscle, kidney and pancreas of CDs/y and CDr/y on RD or DD. *P

Impact of low-level galactose exposure on acute and long-term outcomes in GALT-null Drosophila. Impact of low-level galactose exposure on acute and long-term.

Tamoxifen injections cause dose-dependent lethal heart failure in αMHC-MerCreMer mice. Tamoxifen injections cause dose-dependent lethal heart failure in.

Effect of Dipy on the expression of chondrogenic markers.

Expression of transgenic IGF-1Ea propeptide in the skin reduces the severity of contact hypersensitivity responses. Expression of transgenic IGF-1Ea propeptide.

Impact of maternal loading for GALK on survival of larvae to adulthood in the presence versus absence of 200 mM dietary galactose. Impact of maternal loading.

MMP-9 expression. MMP-9 expression. (A) Lungs from M. tuberculosis-infected (H37Rv, 14 wpi, untreated) and age-matched uninfected (control) mice were harvested.

Fgfr3;4 mutant lungs display an increase in Mfap5, Igf1 and Fbn2 expression. Fgfr3;4 mutant lungs display an increase in Mfap5,Igf1and Fbn2 expression.

Cross-validation between centres for inbred mice.

Gα12 is not required for hepatic cystogenosis induced by Pkd1 knockout

Pgc-1α+/− mice show an increased inflammatory response to LPS injection. Pgc-1α+/− mice show an increased inflammatory response to LPS injection. (A) RPE/retina.

Chd1 expression and CHD1 localization during mouse preimplantation development. Chd1 expression and CHD1 localization during mouse preimplantation development.

Peroxisome speeds were slower in patient and control cells.

Fig. 7. Nrf2-dependent enzyme activities in wild-type, Nrf2- and Keap1-deficient tissues.Hepatic (A,C,E) and cortical (B,D,F) enzyme activities of NQO1.

Proliferative and morphological defects following TbCALM and TbEpsinR depletion. Proliferative and morphological defects following TbCALM and TbEpsinR.

Human IL-10 neutralization results in inhibited expression of intragraft Treg function genes and production of suppressive cytokine IL-10. Human IL-10.

BCL-3 regulates expression of stemness-associated Wnt targets.

Effect of siRNA transfection on colony formation by Renca cells.

Functional and molecular regeneration in mdx muscle with matrix treatment. Functional and molecular regeneration in mdx muscle with matrix treatment. (A,B)

Upon challenge with oxazolone, human leukocytes (mainly consisting of T cells) infiltrate the dermis and epidermis. Upon challenge with oxazolone, human.

Figure 3 Within-group comparisons (before–after)‏

Presentation transcript:

Silencing of Keap1 reduced the expression of inflammatory markers in ConA-injected livers. Silencing of Keap1 reduced the expression of inflammatory markers in ConA-injected livers. Analysis of inflammatory markers in liver samples from luciferase siRNA (siLuc) or Keap1 siRNA (siKeap1) mice after 4 and 8 hours of ConA treatment (n=4–6 animals per condition). (A,B) mRNA levels of the indicated cytokines and pro-inflammatory markers determined by real-time PCR. Data are presented as mean±s.e.m. relative to siLuc mice. *P<0.05, **P<0.01 and ***P<0.005, siKeap1 versus siLuc. Águeda González-Rodríguez et al. Dis. Model. Mech. 2014;7:1093-1100 © 2014. Published by The Company of Biologists Ltd