Central nervous system BDNF infusion fails to increase tissue glucose uptake in uncontrolled insulin-deficient diabetes. Central nervous system BDNF infusion.

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Central nervous system BDNF infusion fails to increase tissue glucose uptake in uncontrolled insulin-deficient diabetes. Central nervous system BDNF infusion fails to increase tissue glucose uptake in uncontrolled insulin-deficient diabetes. Tissue glucose uptake (Rg) determined from 2[14C]-deoxyglucose studies in tibialis anterior muscle (A) and BAT (B) and BAT expression of uncoupling protein-1 (Ucp1) (C) and peroxisome proliferator–activated receptor γ-coactivator-1 α (Pgc-1α) (D) in nondiabetic controls or in STZ-induced diabetic animals receiving intracerebroventricular vehicle and pair-fed or intracerebroventricular BDNF (n = 5–6 per group). Data represent mean ± SEM. *P < 0.05 vs. veh-veh. Thomas H. Meek et al. Diabetes 2013;62:1512-1518 ©2013 by American Diabetes Association