Tibolone reverses the cognitive effects caused by leuprolide acetate administration, improving mood and quality of life in patients with symptomatic uterine.

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Presentation transcript:

Tibolone reverses the cognitive effects caused by leuprolide acetate administration, improving mood and quality of life in patients with symptomatic uterine leiomyomas Stefano Palomba, M.D., Francesco Orio, M.D., Angela Falbo, M.D., Rosamaria Oppedisano, M.D., Achille Tolino, M.D., Fulvio Zullo, M.D. Fertility and Sterility Volume 90, Issue 1, Pages 165-173 (July 2008) DOI: 10.1016/j.fertnstert.2007.05.061 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Flow diagram of the clinical trial according to the Consolidated Standards of Reporting of Trials guidelines (38). Fertility and Sterility 2008 90, 165-173DOI: (10.1016/j.fertnstert.2007.05.061) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Mean percent change (±SD) from baseline after 6 months of treatment in uterine and leiomyoma dimensions in groups A and B. ∗P<.05 vs. baseline. Fertility and Sterility 2008 90, 165-173DOI: (10.1016/j.fertnstert.2007.05.061) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Mean percent change (±SD) from baseline after 6 months of treatment in WMS scores for each domain assessed in groups A and B. ∗P<.05 vs. baseline. °P<.05 vs. group B. Fertility and Sterility 2008 90, 165-173DOI: (10.1016/j.fertnstert.2007.05.061) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions