The abundance and expression of miRNAs.

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The abundance and expression of miRNAs. The abundance and expression of miRNAs. (A) C. elegans miRNA sequencing data ranked by the maximal expression at any developmental stage. miRNAs were sequenced from whole embryos (E) or larvae (L1 to L4). Data are replotted from Kato et al. (2009). The miRNAs mentioned in the main text are highlighted and the expression patterns of some of these (based on transcriptional reporters) is shown to the right to highlight the correlation between expression level and pattern. The high abundance of the mir-35 cluster, for example, correlates with its broad expression. Several seemingly low abundance miRNAs, such as lsy-6 and mir-791, are expressed in a highly restricted manner. The lsy-6 expression pattern is reproduced with permission, from Cochella and Hobert, 2012a. The mir-791 expression pattern is reproduced from Drexel et al., 2016. (B) miRNA sequencing data from zebrafish embryos ranked as for C. elegans. Data are replotted from Yao et al. (2014). Expression patterns of selected miRNAs (as detected by in situ hybridization) are reproduced with permission from Wienholds et al. (2005). hpf, hours post-fertilization. Chiara Alberti, and Luisa Cochella Development 2017;144:2548-2559 © 2017. Published by The Company of Biologists Ltd