Mst Out and HCC In Cancer Cell

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Mst Out and HCC In Cancer Cell Bin Zhao, Qunying Lei, Kun-Liang Guan Cancer Cell Volume 16, Issue 5, Pages 363-364 (November 2009) DOI: 10.1016/j.ccr.2009.10.008 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Cell-Type-Dependent Variation of the Hippo Pathway (A) A generally accepted paradigm of the Hippo pathway. (B) Hippo pathway in liver and cultured hepatocytes. Cleaved Mst1/2 activate an unknown kinase of YAP, and Lats1/2 may phosphorylate YAP once activated by a kinase distinct from Mst1/2. (C) Hippo pathway in MEF cells. High cell density activates an elusive kinase to activate Lats1/2 and stimulate phosphorylation of YAP. Mst1/2 are not required for YAP phosphorylation in MEFs. Cancer Cell 2009 16, 363-364DOI: (10.1016/j.ccr.2009.10.008) Copyright © 2009 Elsevier Inc. Terms and Conditions