Comparative single cell transcriptional profiling of standard kidney organoids and micro-organoids demonstrates an equivalent nephrogenic patterning. Comparative.

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inhibits BMP signalling.

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Volume 21, Issue 11, Pages (December 2017)

A Single-Cell Transcriptome Atlas of the Human Pancreas

Structure of abbreviated dystrophins.

LincRNAs expressed in specific subpopulations of mESCs and NPCs.

Patient neural progenitors show a neurodevelopmental phenotype.

Volume 21, Issue 11, Pages (December 2017)

Individual genes exhibit distinct female-enriched expression patterns.

Significant differences in translational efficiencies of DNA damage repair pathway genes between patient clusters. Significant differences in translational.

Differential protein, mRNA, lncRNA and miRNA regulation by p53.

ACF1 loss perturbs gene expression in early embryos.

Expression profiles of 5,493 transcripts grouped by k-means clustering

CiCo relation to linear transcripts.

Fig. 2. Morphological changes of cultured adherent fibroblastic cells after OA treatment related to actin microfilament reorganization.(A) Cells observed.

Nephrogenesis in vitro can be rescued in 3D co-cultures by siRNA treatment of Renca cells. Nephrogenesis in vitro can be rescued in 3D co-cultures by siRNA.

Fig. 7. Motion adaptation increases time-dependent response modulations (TDRM) relatively to the average cell response.TDRM normalized to the value obtained.

A highly conserved six-amino-acid region in the C-terminal CT domain of MARCH8 is responsible for its ability to downregulate TfR. A highly conserved six-amino-acid.

Altered oligodendrocyte progenitor cell (OPC) marker protein expression in two white matter regions of ShhΔFP/ΔFP and SmoΔNT/ΔNT embryos at E15.5. Altered.

Notch pathway components in serial sections of the human colon.

Expression of Shh-Gli target genes in astrocyte progenitors.

Smo deficiency in the renal stroma is dependent on GLI3R.

Neutralization and knockdown of TGFβ2 results in fewer nephrons ex vivo. Neutralization and knockdown of TGFβ2 results in fewer nephrons ex vivo. (A,B)

Ingenuity pathway analysis of the genes enriched in both 96-h-induced MMs and human ccRCC. Ingenuity pathway analysis of the genes enriched in both 96-h-induced.

Directed differentiation of hPSCs to hypothalamic progenitors.

Patient and control ONS cells had very large differences in gene expression. Patient and control ONS cells had very large differences in gene expression.

Linear relationship between the measured rate of blood flow to the systemic circuit () and rate of blood flow through the left aorta () at 0, 12 and 24 h.

Setdb1 has cell-intrinsic functions in B cell development.

Extended micro-organoid culture.

R Packages for Single-Cell RNA-Seq

Transcription factor network of human pancreas development.

Effects of the ft-overexpressing clones in A and P compartments (cf.

Fig. 6. STK35 KO mice show ovary defects.

BMP signalling is dispensable for early gastruloid patterning.

Fig. 6. Apical polarity of primitive endoderm cells on surface of embryoid bodies.Embryoid bodies were analyzed by immunofluorescence microscopy for GATA4.

Distribution and extent of expression.

Comparison ofMyc-induced zebrafish liver tumors with different stages of human HCC and seven mouse HCC models. Comparison ofMyc-induced zebrafish liver.

Functional classification and visualization of differentially expressed genes. Functional classification and visualization of differentially expressed.

Statistical chart of significantly differentially expressed genes

Fate of Kmt2b target genes.

Fig. 1. Phenotypic characterisation of primary human tubular epithelial cells and human renal fibroblasts. Phenotypic characterisation of primary human.

Effect of Dipy on the expression of chondrogenic markers.

Variable number of CD4-CTL precursors across donors.

The transcriptional activation activity of PIFs is higher in the cop1-4hfr1 background compared with the cop1-4 background. The transcriptional activation.

Differential optogenetic stimulation of Rac and Cdc42 induces lamellipodia and directed migration on a FN substrate. Differential optogenetic stimulation.

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CD4-TEMRA cells are heterogeneous across donors.

Spinal cord-like tissues were ventralized by activating Shh signaling in a dose-dependent manner. Spinal cord-like tissues were ventralized by activating.

Stage-specific expression modules of preimplantation development.

Global analysis of human, marmoset and mouse preimplantation stages.

Organoid-derived transplantable corneal epithelial grafts on human amniotic membrane substrate. Organoid-derived transplantable corneal epithelial grafts.

CD4+CLA+CD103+ T cells from human blood and skin share a transcriptional profile. CD4+CLA+CD103+ T cells from human blood and skin share a transcriptional.

ITSN1 recruitment stimulates cellular FN deposition to stabilize lamellipodia. ITSN1 recruitment stimulates cellular FN deposition to stabilize lamellipodia.

Conserved and divergent elements of EPI and PrE transcription factor networks. Conserved and divergent elements of EPI and PrE transcription factor networks.

Microarray analysis of DRG explant cultures of wild-type and ErbB3-deficient mice. Microarray analysis of DRG explant cultures of wild-type and ErbB3-deficient.

Effects of Chd1-knockdown on global gene expression.

The transposcriptome in preimplantation development.

HFHC/STZ guinea pigs develop insulin-independent diabetes that is responsive to oral antihyperglycemic therapy. HFHC/STZ guinea pigs develop insulin-independent.

Peroxisome speeds were slower in patient and control cells.

Fig. 2. Temporal map of genes clustering with the expression profile of Lmx1a.(A) Heat-map visualization obtained by HCL of genes clustering with Lmx1a.

Proliferative and morphological defects following TbCALM and TbEpsinR depletion. Proliferative and morphological defects following TbCALM and TbEpsinR.

CD25 expression identifies two transcriptionally distinct subsets of very early effector cells. CD25 expression identifies two transcriptionally distinct.

Lack of Ctip2 is associated with impaired proliferation and delayed onset of differentiation during early stages of epidermal development. Lack of Ctip2.

Volume 12, Issue 4, Pages (April 2019)

Disruption of the tubule formation by immortalized cells during nephrogenesis in vitro. Disruption of the tubule formation by immortalized cells during.

Loss of BAP1 blocks T cell differentiation at the DN3 stage in vitro.

Ca2+-mediated differentiation of primary mouse keratinocytes is independent of epiplakin. Ca2+-mediated differentiation of primary mouse keratinocytes.

APLF regulates genes implicated in MET during the generation of iPSCs from fibroblasts. APLF regulates genes implicated in MET during the generation of.

Distinct subtypes of CAFs are detected in human PDAC

Single-cell analysis uncovers ductal cell subpopulations in human PDAC

Volume 27, Issue 7, Pages e4 (May 2019)

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Comparative single cell transcriptional profiling of standard kidney organoids and micro-organoids demonstrates an equivalent nephrogenic patterning. Comparative single cell transcriptional profiling of standard kidney organoids and micro-organoids demonstrates an equivalent nephrogenic patterning. (A) t-SNE plots after integrated Seurat analysis of kidney micro-organoid and standard organoid 10x scRNA-seq data from day 7+18 (CRL1502.32 cells) (Combes et al., 2019). (B) t-SNE plot representing micro-organoid (Micro-org; pink) and standard organoid (Stand-org; blue) contributions to cell types in each cluster. (C) Bar graph representing the proportion of each of the Micro-org or Stand-org datasets assigned to each transcriptional cluster and differentiation lineage type. (D) Split dot plots showing the gene expression of kidney markers in each cluster between kidney micro-organoids and standard organoid. (E) Violin and scatter plots showing the log-normalised counts per cell for nephron-related (PAX2, SIX1, LHX1) and stromal-related (PDGFRA, MEIS2) genes within Micro-org and Stand-org. (F) Immunofluorescence showing the expression of PAX2 and MEIS1/2/3 between kidney Micro-org and Stand-org. Scale bars: 50 µm. Santhosh V. Kumar et al. Development 2019;146:dev172361 © 2019. Published by The Company of Biologists Ltd