A randomized, double-blind trial of the effect of treatment with montelukast on bronchial hyperresponsiveness and serum eosinophilic cationic protein.

Slides:

Advertisements

Similar presentations

W.Travis Cain, MDa, Greg Cable, PhDb, John J. Oppenheimer, MDc

Advertisements

Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor.

Double-blind placebo-controlled study of the efficacy of oral terfenadine in the treatment of chronic fatigue syndrome Paul Steinberg, MDa, Bruce E.

Diane J. Pincus, MD, Stanley J. Szefler, MD, Lynn M

The editors’ choice Journal of Allergy and Clinical Immunology

Comparative efficacy and anti-inflammatory profile of once-daily therapy with leukotriene antagonist or low-dose inhaled corticosteroid in patients with.

A randomized, vehicle-controlled trial of tacrolimus ointment for treatment of atopic dermatitis in children Mark Boguniewicz, MDa, Virginia C. Fiedler,

Montelukast treatment may alter the early efficacy of immunotherapy in children with asthma Paweł Majak, MD, PhD, Błażej Rychlik, PhD, Łukasz Pułaski,

Allergen vaccination with a liposome-encapsulated extract of Dermatophagoides pteronyssinus : A randomized, double-blind, placebo-controlled trial in.

Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma Patrick Booms, MSca, David.

Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema Dagmar Simon, MD, Jennifer Wittwer, MD, Ganna Kostylina,

Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin a- induced bronchoconstriction Nunzio Crimi, MD, Corrado Pagano, MD,

Asthma and increased bronchial responsiveness in elite athletes: Atopy and sport event as risk factors Ilkka J. Helenius, MDa, Heikki O. Tikkanen, MDb,

Rosa Codina, PhD, Richard F. Lockey, MD

The effect of omalizumab on nasal allergic inflammation

Comparison of once-daily ebastine 20 mg, ebastine 10 mg, loratadine 10 mg, and placebo in the treatment of seasonal allergic rhinitis Paul H. Ratner,

Soluble intercellular adhesion molecule-1 levels of patients with acute myeloid leukemia after allogeneic bone marrow transplantation Yasuhiro Maeda,

Badrul A. Chowdhury, MD, PhD

Hydroxychloroquine improves airflow and lowers circulating IgE levels in subjects with moderate symptomatic asthma B.Lauren Charous, MD, Elkan F. Halpern,

Adverse effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors associated with elevated serum IgE and eosinophilia Carol K. Fosso, MDa,

Comparison of a nasal glucocorticoid, antileukotriene, and a combination of antileukotriene and antihistamine in the treatment of seasonal allergic rhinitis

Allergy to eggs from duck and goose without sensitization to hen egg proteins Belén Añíbarro, MD, F.Javier Seoane, MD, Concepción Vila, MD, Manuel Lombardero,

Elephantiasis nostras: A case report

Low-dose fluticasone propionate compared with montelukast for first-line treatment of persistent asthma: A randomized clinical trial William Busse, MDa,

The impact of allergic rhinitis on bronchial asthma

Serum levels of eosinophil cationic protein in allergic diseases and natural allergen exposure Margherita Tomassini, MDa, Laura Magrini, MDa, Guido De.

Jaring S. van der Zee, a, Koos S. N. de Jager, b, Bart F

A review of the current guidelines for allergic rhinitis and asthma

Evidence for expression of eosinophil-associated IL-12 messenger RNA and immunoreactivity in bronchial asthma Esra Nutku, MDa, Abdelilah Soussi Gounni,

Pathophysiology of the inflammatory response

News & Notes Journal of Allergy and Clinical Immunology

Circadian variation of sputum inflammatory cells in mild asthma

Anaphylactic Reaction to White-Faced Hornet Sting and Elevated Baseline (Asymptomatic) Serum Tryptase Phillip Lieberman, MD, Lawrence B. Schwartz, MD,

Inflammatory cells, cytokine and chemokine expression in asthma immunocytochemistry and in situ hybridization Qutayba Hamid, MD, PhD, Editor Journal.

Salmeterol and fluticasone propionate combined in a new powder inhalation device for the treatment of asthma: A randomized, double-blind, placebo-controlled.

The editors' choice Journal of Allergy and Clinical Immunology

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Claus Bachert, MD, PhD, Cezmi A. Akdis, MD

Effect of ozone and nitrogen dioxide on the release of proinflammatory mediators from bronchial epithelial cells of nonatopic nonasthmatic subjects and.

Efficacy of nebulized budesonide in treatment of severe infantile asthma: A double-blind study Jacques de Blic, MDa, Christophe Delacourt, MDa, Muriel.

Budesonide delivered by Turbuhaler is effective in a dose-dependent fashion when used in the treatment of adult patients with chronic asthma William.

What is an “eosinophilic phenotype” of asthma?

Subjective and objective assessments in patients with seasonal allergic rhinitis: Effects of therapy with mometasone furoate nasal spray Eli O. Meltzer,

Molecular virology and immunology of HIV infection

Exercise-induced bronchoconstriction in children: Montelukast attenuates the immediate-phase and late-phase responses Raul E. Melo, MD, Dirceu Solé,

News & Notes Journal of Allergy and Clinical Immunology

Low-dose inhaled fluticasone propionate versus oral zafirlukast in the treatment of persistent asthma Eugene R. Bleecker, MDa, Michael J. Welch, MDb,

Effect of rush immunotherapy on airway inflammation and airway hyperresponsiveness after bronchoprovocation with allergen in asthma Yasurou Kohno, MDa,

Omalizumab improves asthma-related quality of life in patients with severe allergic asthma Albert Finn, MDa, Gary Gross, MDb, Julius van Bavel, MDc,

The 30th anniversary of the American Board of Allergy and Immunology: Then and now Lynn Des Prez a, Charles E. Reed, MD, Lawrence B. Schwartz, MDb, John.

Intracellular IL-5 and T-lymphocyte subsets in atopic and nonatopic bronchial asthma Yutaro Shiota, MD, PhDa, Hitomi Arikita, MTa, Naokatsu Horita, MDb,

Chemokines in seasonal allergic rhinitis

Preparing patients and health professionals for the transition to chlorofluorocarbon-free inhalers: The British perspective Helen Donohoe, MSc (Econ)

Mometasone furoate administered once daily is as effective as twice-daily administration for treatment of mild-to-moderate persistent asthma James P.

Changes in sputum counts and airway hyperresponsiveness after budesonide: Monitoring anti-inflammatory response on the basis of surrogate markers of airway.

Determinants of systemic manifestations of food allergy

Diane J. Pincus, MD, Stanley J. Szefler, MD, Lynn M

Effect of continuing or finishing high-level sports on airway inflammation, bronchial hyperresponsiveness, and asthma: A 5-year prospective follow-up.

Prescott G. Woodruff, MD, MPH, Ramin Khashayar, MD, Stephen C

IL-18 might reflect disease activity in mild and moderate asthma exacerbation Hiroshi Tanaka, MD, Naomitsu Miyazaki, MD, Kensuke Oashi, MD, Shin Teramoto,

Larry C. Borish, MDa, Harold S

Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challenge Vernon M. Chinchilli, PhD, Laura Fisher, MD, Timothy.

The environmental predictors of allergic disease

Interrupting IL-6–receptor signaling improves atopic dermatitis but associates with bacterial superinfection Alexander A. Navarini, MD, PhD, Lars E.

Airway remodeling-associated mediators in moderate to severe asthma: Effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression

Bruce K. Bacot, MD, Mary E. Paul, MD, Maritza Navarro, MD, Stuart L

Asthma symptoms and airway hyperresponsiveness are lower during treatment with nedocromil sodium than during treatment with regular inhaled albuterol

News & Notes Journal of Allergy and Clinical Immunology

Systemic responses after bronchial aspirin challenge in sensitive patients with asthma Joanna S. Makowska, MD, PhD, Janina Grzegorczyk, PhD, Barbara Bienkiewicz,

Natural history of cow’s milk allergy

Presentation transcript:

A randomized, double-blind trial of the effect of treatment with montelukast on bronchial hyperresponsiveness and serum eosinophilic cationic protein (ECP), soluble interleukin 2 receptor (sIL-2R), IL-4, and soluble intercellular adhesion molecule 1 (sICAM-1) in children with asthma Iwona Stelmach, MD, PhDa, Joanna Jerzynska, MDa, Piotr Kuna, MD, PhD, Profb Journal of Allergy and Clinical Immunology Volume 109, Issue 2, Pages 257-263 (February 2002) DOI: 10.1067/mai.2002.121456 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 Serum sICAM-1 levels (ng/mL) before and after treatment with montelukast (left panel ) and placebo (right panel ). The symbol — indicates mean value. p 1, Changes from baseline within each group; p 2, changes between groups before treatment; p 3, changes between groups after treatment. Journal of Allergy and Clinical Immunology 2002 109, 257-263DOI: (10.1067/mai.2002.121456) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 2 Serum ECP levels (μg/L) before and after treatment with montelukast (left panel ) and placebo (right panel ). The symbol — indicates mean value. p 1, Changes from baseline within each group; p 2, changes between groups before treatment; p 3, changes between groups after treatment. Journal of Allergy and Clinical Immunology 2002 109, 257-263DOI: (10.1067/mai.2002.121456) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 3 FEV1 (percentage of predictive value) before and after treatment in montelukast (left panel ) and placebo group (right panel ). The symbol — indicates mean value. p 1, Changes from baseline within each group; p 2, changes between groups before treatment; p 3, changes between groups after treatment. Journal of Allergy and Clinical Immunology 2002 109, 257-263DOI: (10.1067/mai.2002.121456) Copyright © 2002 Mosby, Inc. Terms and Conditions