CASE REVIEW 2019-03-14 강동경희대병원 이한나.

Slides:

Advertisements

Similar presentations

FOLLICULAR DENDRITIC CELL SARCOMA R4 洪逸平 /VS 顏厥全大夫財團法人台灣癌症臨床研究發展基金會.

Advertisements

Adamantinoma Ted Scriven Sept 15 th, Adamantinoma is a malignant bone tumour Definition.

Case Study 61 Kenneth Clark, MD. Question 1 This is a 31-year-old asymptomatic man who was found to have papilledema on a routine ophthalmologic examination.

Malignant Adenomyoepithelioma of the Breast with Lymph Node Metastasis

Carcinoid tumors. Develop from the argyrophillic Kulchitsky’s cells that are present in the airway mucosa Neuroendocrine tumor categorized Grade I : typical.

Case Report History :26 year old caucasian male presented complaining of an intra oral swelling involving the gum margin of the upper left jaw. He gave.

NEOPLASIA (Malignant Tumors)

Francisco G. La Rosa MD Pathologist, Assistant Professor Department of Pathology, UCHSC * In collaboration with * In collaboration with S. Russell Nash,

Proliferative Epithelial lesions of the Breast

Case 1 SRDP, Sibiu, october Authors: Sabina Zurac 1, Razvan Andrei 1, Tiberiu Tebeica 1, Florica Staniceanu 1, Adrian Rebosapca, Bogdan Andreescu.

DS Ross,1 DD Giri,1 MM Akram,1 JP Catalano,1

Neuroradiology-Neuropathology Conference May, 2011 Michael Solle, MD Tom Bouldin, MD.

A 70 years old woman with a left lung nodule General weakness 가 5 개월 전부터 간헐 적으로 있었으며, 1 개월 전 local clinic 에서 시행한 chest PA 와 chest CT 상 left lung 에 13mm.

Lananh Nguyen, M.D. Division of Neuropathology University of Pittsburgh Medical Center 3-year-old boy presenting with exopthalmos.

Diagnostic Challenge Pathology for Neurosurgery & Neurology Residents Department of Pathology University of Oklahoma Health Sciences Center, Oklahoma City,

First author: Roman Adina Co-author: Andone Sebastian

Esophagus cancer Dr Sanei Associated professor of pathology GI and Liver patholoogist.

 Aggressive Angiomyxoma (AA) is a very rare tumor. It was first described in 1983 and since then only about 250 cases have been reported  Women.

SOLITARY METASTASIS OF RENAL CLEAR CELL CARCINOMA TO HÜRTHLE CELL ADENOMA OF THYROID GLAND: REPORT OF A CASE RITA PASSANTINO - LORENZO MARASA’ Department.

Soft tissue Tumors II. Lecture 36 : Soft tissue tumors II At the end of session the student should be able to: Discuss benign and malignant fibrohistiocytic.

Rare Airway Tumors - Malignant Marwan Saoud MD, Kassem Harris MD, FCCP Co-Chair: WABIP Rare Lung, Pleura & Airway Disorders.

بنام خدا. Synovial sarcomas include monophasic, biphasic, and poorly differentiated (“round cell”) variants. Monophasic synovial sarcoma shows considerable.

Liver mass Mazen Hassanain. Radiology Arterial enhancement: adenoma, FNH, hemangioma, HCC, NET mets Portal enhancement: CRC liver mets.

Differential Diagnosis

Case 11/2011 B. Lach Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ont. CANADA Abbreviations used: B-brain, M-meningioma,

A Signet Ring Cell Tumor of The Ovary, Diagnosed After Treatment of Hodgkin lymphoma The First Case Of The Literature Dr. Sakir Volkan Erdogan Bakirkoy.

Case Rep Gastroenterol 2015;9: DOI: /

Woo Cheal Cho MD1, Fabiola Balarezo, MD1

CASE STUDY Dr. Alireza Azimi 92/10/21.

Discussion & Conclusion Predictives of Meningioma Grading

Case Study 14 Gabrielle Yeaney, M.D..

Figure 4. Histologic, immunohistochemical analyses of inflammatory myofibroblastic tumor (IMT) at metastasis diagnosis after complete surgical resection.

Meningeal tumor pathology

Gliomatosis cerebri with spinal metastasis presenting with chronic meningitis in two boys Yi-Heng Lin, Yen-Wen Chang, Shih-Hung Yang, Hsiu-Hao Chang,

In the name of GOD.

INTRANEURAL SCHWANNOMA. AN INCIDENTAL OBSERVATION.

Solid pseudopapillary tumour of the pancreas: Incidence, prognosis and outcome of surgery (single center experience) Ayman El Nakeeb, Mohamed Abdel Wahab,

Chapter 14 Hepatic Tumors, Malignant 1

Volume 1, Issue 6, Pages S8-S11 (November 2015)

A case of intravascular epithelioid hemangioendothelioma occurring 14 years after coil embolization for an extracranial internal carotid artery aneurysm

Next Generation Sequencing Uncovers Potential Genetic Driver Mutations of Malignant Pulmonary Granular Cell Tumor Song Xu, Qingchun Zhao, Sen Wei, Yi.

Case Study 41 Henry Armah, M.D., M.Phil..

A Rare Cause of Postoperative Hypotension

Response to Crizotinib/Erlotinib Combination in a Patient with a Primary EGFR-Mutant Adenocarcinoma and a Primary c-met–Amplified Adenocarcinoma of the.

A Rarity in a Common Disease: Thyroid Paraganglioma

SOFT TISSUE & SKELETAL SYSTEM LABORATORY

Sclerosing Pneumocytoma with Lymph Node Metastasis

Case Study 37 Henry Armah, M.D., M.Phil..

Case 1 South Bay Pathology Society May 2009

Tumor-to-Tumor Metastasis: Maxillary Sinus Adenoid Cystic Carcinoma Metastasizing to Double Primary Lung Adenocarcinoma Wei-Yang Lin, MD, Wen-Hu Hsu,

Improving the Accuracy of Mesothelioma Diagnosis in China

Small Cell Transformation and T790M Mutation as Coresistance Mechanisms for First- line Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor.

Large Clear Cell Tumor of the Lung Mimicking Malignant Behavior

AMR Seminar Symposium Split, Croatia Case #63

흉부영상집답회 case review 강동경희대병원 이한나.

Case Study 35 Henry Armah, M.D., M.Phil..

Lung Metastases from Esophageal Granular Cell Tumor: An Undoubted Criterion for Malignancy Isidro Machado, MD, PhD, Julia Cruz, MD, PhD, Estanislao Arana,

Adnan M. Al-Ayoubi, MD, Jonathan S. Ralston, MD, S

Mark L. Kayton, MD, Mai He, MD, PhD, Maureen F. Zakowski, MD, Andre L

Complete Resection of Oligorecurrence of Stage I Lung Adenocarcinoma 19 Years After Operation Dai Sonoda, MD, Masashi Mikubo, MD, Kazu Shiomi, MD, PhD,

Transformation to SCLC after Treatment with the ALK Inhibitor Alectinib Shiro Fujita, MD, PhD, Katsuhiro Masago, MD, PhD, Nobuyuki Katakami, MD, PhD,

Bronchial Oncocytoma With High 18F-Fluorodeoxyglucose Uptake Revealed by Nephrotic Syndrome Giovanni Leuzzi, MD, Alfredo Cesario, MD, Marco Chiappetta,

A case of intravascular epithelioid hemangioendothelioma occurring 14 years after coil embolization for an extracranial internal carotid artery aneurysm

A Clear Cell Tumor of the Lung Presenting as a Rapidly Growing Coin Lesion: Is It Really a Benign Tumor? Alexandros Kalkanis, MD, Myrto Trianti, MD,

Nonintubated thoracoscopic surgery for pulmonary lesions in both lungs

Neuroendocrine Cancer of the Lung: A Diagnostic Puzzle

PEComa (Clear Cell “Sugar” Tumor) of the Lung: A Benign Tumor That Presented With Trombocytosis Serdar Sen, MD, Ekrem Senturk, MD, Nilgun Kanlıoglu Kuman,

Marián Švajdler UNLP Košice

Presentation transcript:

CASE REVIEW 2019-03-14 강동경희대병원 이한나

CASE 58/M C.C : incidentally detected abnormal finding on chest radiograph

18 months ago

A 2.7cm, well-defined nodule in the LLL, no significant interval change. -> d/dx 1) r/o) carcinoid tumor 2) r/o) sclerosing pneumocytoma

26.5 mm . 1 year later

7 years ago 6.5 years ago 16.0 mm 4.5 years ago 18months ago

Hospital course Video‑assisted thoracoscopic wedge resection (2014-08-27)

Periodic acid‑Schiff‑positive Human melanoma black (HMB)‑45

Pathologic report Lung, lower lobe, left, wedge resection: Clear cell tumor 1) size: 2.7 x 2.5 x 2.4 cm 2) mitosis: 1/50 HPFs 3) no necrosis, no atypia 4) clear resection margin [SPECIAL & IMMUNOHISTOCHEMICAL STAIN] SMA, ACTIN (Smooth Muscle) [B03] : negative CD 34 [B03] : positive CHROMOGRANIN A [B03] : negative CK, AE1/AE3 [B03] : negative EMA (Epithelial Membrane Ag) [B03] : negative KI-67 (MIB1) [B03] : about 5% Melanosome (HMB-45) [B03] : positive, focal 　　　S-100 [B03] : positive, focal 　　　SYNAPTOPHYSIN [B03] : negative 　　　TTF-1 (Thyroid Transcription Factor) [B03] : negative 　　　VIMENTIN [B03] : positive 　　　Melanosome (HMB-45) [B04] : positive, focal 　　　D-PAS [B04] : positive 　　　PAS (Periodic acid Schiff) [B04] : positive

Clear cell tumor of the lung (CCTL) The family of perivascular epithelioid cell tumor (PEComa) (2004 WHO classification) Very rare benign mesenchymal tumor from perivascular epithelioid cells Consist with clear cells with a large amount of cytoplasmic PAS‑positive glycogen = sugar tumor Well-defined margin and homogenous intense enhancement Rich vascular stroma

Surgical resection for diagnosis and curative treatment Clear cell tumor of the lung (CCTL) Generally regarded as benign Malignant behavior : local invasion Possibility of malignant potential Necrosis, a mitotic index of > 1 per 50 high‐power fields, marked pleomorphism, and nuclear atypia Surgical resection for diagnosis and curative treatment

Clear cell tumor of the lung (CCTL) Difficult to identify the interval growth pattern of CCTL. In our case Initially gradual interval growth  Remained 2.7 cm for next 2.5 years Ann Thorac Surg. 2011 Feb;91(2):588-91 Gradually grow over five years 1.0cm after 12 months doubling volume time : 120days