Cyp8b1−/− mice have improved islet insulin secretion and increased islet insulin content but unchanged β-cell mass. Cyp8b1−/− mice have improved islet.

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Cyp8b1−/− mice have improved islet insulin secretion and increased islet insulin content but unchanged β-cell mass. Cyp8b1−/− mice have improved islet insulin secretion and increased islet insulin content but unchanged β-cell mass. A: In vivo glucose-stimulated insulin secretion (GSIS) in control (+/+) and Cyp8b1−/− (−/−) mice after an oral glucose load after a 4-h fast (n = 4–7). B: Islet insulin content in control (+/+) and Cyp8b1−/− (−/−) mice (n = 4–5). C: Ex vivo GSIS from control (+/+) and Cyp8b1−/− (−/−) islets (n = 3–5). D: β-Cell mass in control (+/+) and Cyp8b1−/− (−/−) mice (n = 4). E: Representative images at original magnification ×10 of control (+/+) and Cyp8b1−/− (−/−) mice stained for insulin (red) and DAPI (blue). Data are shown as mean ± SEM. *P < 0.05 by two-way ANOVA, followed by the Bonferroni post hoc test for in vivo GSIS, and *P < 0.05 by Student t test for insulin content and ex vivo GSIS. Achint Kaur et al. Diabetes 2015;64:1168-1179 ©2015 by American Diabetes Association