Effects of supplemental oxygen and dexamethasone on surgical site infection: a factorial randomized trial‡ A. Kurz, E. Fleischmann, D.I. Sessler, D.J.

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Effects of supplemental oxygen and dexamethasone on surgical site infection: a factorial randomized trial‡ A. Kurz, E. Fleischmann, D.I. Sessler, D.J. Buggy, C. Apfel, O. AkçaFleischmann Edith , Erdik Erol , Eredics Klaus , Kabon Barbara , Herbst Friedrich , Kazerounian Sara , Kugener Andre , Marschalek Corinna , Mikocki Pia , Niedermayer Monika , Obewegeser Eva , Ratzenboeck Ina , Rozum Romana , Sindhuber Sonja , Schlemitz Katja , Schebesta Karl , Stift Anton , Kurz Andrea , Sessler Daniel I. , Bala Endrit , Chen Samuel T. , Devarajan Jagan , Maheshwari Ankit , Mahboobi Ramatia , Mascha Edward , Nagem Hassan , Rajogopalan Suman , Reynolds Luke , Alvarez Adrian , Stocchi Luca , Doufas Anthony G. , Govinda Raghavendra , Kasuya Yusuke , Komatsu Ryu , Lenhardt Rainer , Orhan-Sungur Mukadder , Sengupta Papiya , Wadhwa Anupama , Galandiuk Susan , Buggy Donal , Arain Mujeeb , Burke Siun , McGuire Barry , Ragheb Jackie , Taguchi Akikio A. Kurz, E. Fleischmann, D.I. Sessler, D.J. Buggy, C. Apfel, O. AkçaFleischmann Edith , Erdik Erol , Eredics Klaus , Kabon Barbara , Herbst Friedrich , Kazerounian Sara , Kugener Andre , Marschalek Corinna , Mikocki Pia , Niedermayer Monika , Obewegeser Eva , Ratzenboeck Ina , Rozum Romana , Sindhuber Sonja , Schlemitz Katja , Schebesta Karl , Stift Anton , Kurz Andrea , Sessler Daniel I. , Bala Endrit , Chen Samuel T. , Devarajan Jagan , Maheshwari Ankit , Mahboobi Ramatia , Mascha Edward , Nagem Hassan , Rajogopalan Suman , Reynolds Luke , Alvarez Adrian , Stocchi Luca , Doufas Anthony G. , Govinda Raghavendra , Kasuya Yusuke , Komatsu Ryu , Lenhardt Rainer , Orhan-Sungur Mukadder , Sengupta Papiya , Wadhwa Anupama , Galandiuk Susan , Buggy Donal , Arain Mujeeb , Burke Siun , McGuire Barry , Ragheb Jackie , Taguchi Akikio British Journal of Anaesthesia Volume 115, Issue 3, Pages 434-443 (September 2015) DOI: 10.1093/bja/aev062 Copyright © 2015 The Author(s) Terms and Conditions

Fig 1 Trial diagram. The first 629 subjects were assigned to normocapnia or hypercapnia at an FiO2 of ∼0.80 without dexamethasone (part 1). We used a factorial randomisation for the subsequent 586 subjects who were assigned to normocapnia or hypercapnia, 30% or 80% inspired oxygen, and 4 mg dexamethasone or no dexamethasone (part 2). This report is restricted to part 2. Dex, dexamethasone; FiO2, fraction of inspired oxygen. British Journal of Anaesthesia 2015 115, 434-443DOI: (10.1093/bja/aev062) Copyright © 2015 The Author(s) Terms and Conditions