Decreased P-IR and total FOXO1 levels in an HFS diet.

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Decreased P-IR and total FOXO1 levels in an HFS diet. Decreased P-IR and total FOXO1 levels in an HFS diet. A: Immunostaining for insulin (green), glucagon (blue), and tyrosine P-IR (red) in islets of monkeys after 24 months on SD (top panel), HFS diet (middle panel), or HFS+Resv diet (bottom panel). Scale bar = 20 µm. B: Quantitation of signal intensity for P-IR. Data are shown as the mean ± SEM. *P < 0.05. C: Immunostaining for insulin (green), TO-PRO-3 (blue), and total FOXO1 (red) in islets of monkeys after 24 months on SD (top panel), HFS (middle panel), or HFS+Resv (bottom panel) diets. Scale bar = 20 µm. D and E: Quantitation of signal intensity (D) and mRNA levels (E) for FOXO1. Data are shown as the mean ± SEM. *P < 0.05. Jennifer L. Fiori et al. Diabetes 2013;62:3500-3513 ©2013 by American Diabetes Association