Cellularity of epididymal adipose tissue.

Slides:



Advertisements
Similar presentations
Supplemental figure 1 Adipocyte SVF E CD AB Supplemental figure 1: Impaired expression of Am2 and Ramps in obese mice (A-E) mRNA levels of Am2, Crlr, Ramp1,
Advertisements

Figure 5. Effects of spirit vinegar and natural fermented vinegar products on epidydimal triglyceride content (A), representative findings (B), and adipocyte.
Long-chain fatty acids are less abundant in the cecal contents of coconut oil-fed mice than in the cecal contents of beef tallow-fed mice. Long-chain fatty.
Valsartan Protects Pancreatic Islets and Adipose Tissue From the Inflammatory and Metabolic Consequences of a High-Fat Diet in Mice by Banumathi K. Cole,
Arterioscler Thromb Vasc Biol
Long-chain fatty acids are less abundant in the cecal contents of coconut oil-fed mice than in the cecal contents of beef tallow-fed mice. Long-chain fatty.
Fatty acid composition of beef tallow, soybean oil, and coconut oil and weight of mice fed diets containing those fats. Fatty acid composition of beef.
The adipose tissue of BALB/c scid mice is quantitatively, but not qualitatively, different than that of BALB/c control mice. The adipose tissue of BALB/c.
Potential cellular mechanisms for activating inflammatory signaling
Fig. 6 Transmissibility of adiposity from humanized mice to germ-free recipients. Transmissibility of adiposity from humanized mice to germ-free recipients.
Fig. 1. Body weight gain in Cbx7-KO mice
Supplementation with vitamins C+E significantly inhibited acellular capillaries in diabetic rats and tended to inhibit formation of pericyte ghosts but.
Hyperinsulinemic-euglycemic clamps revealed that obese TPL2KO mice have an improved insulin sensitivity compared with obese WT mice. Hyperinsulinemic-euglycemic.
Lypolytic activity (glycerol release, mg/ml) measured in adipocytes culture medium after 2 h incubation with isoproterenol or 8-Cl-cAMP. Lypolytic activity.
A: Total collagen content by Sirius red staining in cardiac tissue of control (SD) animals. A: Total collagen content by Sirius red staining in cardiac.
Analysis of peripheral blood CD4+CD25+ T-cells after B6
Suggested model of integrated regulation of CCL2 by miRNAs and TFs in human adipocytes and macrophages. Suggested model of integrated regulation of CCL2.
Exogenous CRP administration causes fasting hyperglycemia and hyperinsulinemia without altering body composition. Exogenous CRP administration causes fasting.
Chronic brain insulin infusion reduces liver TG content independent of changes in body weight and food intake. Chronic brain insulin infusion reduces liver.
Omental FFA production, calculated from the integrated lipolysis over the last 30 min of each insulin infusion period. Omental FFA production, calculated.
Activation of β-adrenoceptors improves glucose tolerance in diabetic animals and increases glucose uptake in vivo, ex vivo, and in vitro. Activation of.
α-Cells mainly express SSTR2 and SSTR3
A: The change of plasma glucose in opioid μ-receptor knockout diabetic mice and wild-type controls receiving an oral intake of metformin (100 mg/kg). A:
Prevalence of high SAT or high VAT by BMI category in women (A) and men (B) and by waist circumference category in women (C) and men (D). Prevalence of.
GLUT4 LXRE is required for downregulation of adipose GLUT4 mRNA during fasting and diet-induced obesity. GLUT4 LXRE is required for downregulation of adipose.
Skeletal muscle characteristics of HFD-induced obese mice.
Appearance of insulin in plasma and CSF at different times after the administration of subcutaneous DET and GLAR in mice and the effect of chronic DET.
Smad3-KO adipose tissues have increased FA uptake and β-oxidation.
Relationships between plasma NEFA concentrations and BMI in two cohorts. Relationships between plasma NEFA concentrations and BMI in two cohorts. Black.
TXNIP and caspase-1 protein levels are increased in the adipose tissue of ob/ob mice. TXNIP and caspase-1 protein levels are increased in the adipose tissue.
Dietary regulation of apical GLUT2.
Forefoot peak plantar pressure in diabetic patients without and with mild, moderate, and severe peripheral neuropathy. *Severe and moderate neuropathy.
Loss of protection by linagliptin against obesity-related inflammation and insulin resistance in MIP-1α−/− mice. Loss of protection by linagliptin against.
A–E: Mechanisms underlying the blunted adiponectin secretion in adipocytes from obese/type 2 diabetic mice. A–E: Mechanisms underlying the blunted adiponectin.
Effect of berberine on white adipose tissue mass.
A and B: Intracellular cAMP levels and lipolysis in adipocytes from chow-fed and HFD-fed mice. A and B: Intracellular cAMP levels and lipolysis in adipocytes.
Reduced β-cell mass in MCH-KO mice on normal chow and high-fat diets.
MiRNA expression profiling in adipocytes from wild-type (WT) and leptin-deficient ob/ob mice. miRNA expression profiling in adipocytes from wild-type (WT)
DPP4 release of explants obtained from adipose tissue of lean controls and obese patients before and after bariatric surgery, and linear correlation with.
Treatment of ob/ob mice with TTR-ASOs reduces adipose tissue inflammation. Treatment of ob/ob mice with TTR-ASOs reduces adipose tissue inflammation. A:
Disruption of MAM integrity and insulin signaling in liver of diet-induced diabetic mice. Disruption of MAM integrity and insulin signaling in liver of.
Metabolic parameters of Id1−/− and wild-type mice fed a standard chow diet (hatched bars and striped bars, respectively) or a high-fat diet (black bars.
Effect of Id1 deletion on insulin action in wild-type and Id1−/− mice fed a chow diet (white triangle/striped bar and black triangle/hatched bar, respectively)
Effect of PP on AT morphology and inflammation after 3 days of treatment. Effect of PP on AT morphology and inflammation after 3 days of treatment. A:
MϕRIP140KD mice show browning in vWAT.
Hepatic fuel metabolism in male 5αR1-KO and WT mice
Mice fed GP-SPI diet show improved fasting glucose and oral glucose tolerance. Mice fed GP-SPI diet show improved fasting glucose and oral glucose tolerance.
Treatment of high-fat diet–fed mice with TTR-ASOs decreases circulating TTR and RBP4 levels, and improves insulin sensitivity. Treatment of high-fat diet–fed.
PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded skin. PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded.
MϕRIP140KD mice exhibit improved metabolic phenotypes.
Effects of Rosi treatment on ASKO mice.
Effects of chow-diet feeding on control and TRIB3 MOE mice.
Leucine deprivation increases energy expenditure.
Urinary albumin excretion and histology of glomeruli.
AP2-Cre–mediated IKKβ deletion results in similar defects in adipose remodeling and accentuated inflammatory responses after HF feeding. aP2-Cre–mediated.
SKO mice display hypertrophic cardiomyopathy with systolic and diastolic dysfunction. SKO mice display hypertrophic cardiomyopathy with systolic and diastolic.
High-fat diet–induced glucose intolerance is prevented in ghrelin knockout (Ghr-KO) mice. High-fat diet–induced glucose intolerance is prevented in ghrelin.
A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R mice. A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R.
Mice lacking Y1 receptor in the hematopoietic compartment remain healthy under normal chow feeding conditions. Mice lacking Y1 receptor in the hematopoietic.
IKKβ protects adipocytes from HFD-induced cell death.
Decreased M1 and increased M2 macrophages in eWAT and liver of DIO mice due to linagliptin administration. Decreased M1 and increased M2 macrophages in.
Deficiency of adipocyte IKKβ does not affect diet-induced weigh gain but results in an exaggerated diabetic phenotype when challenged with an HFD. A: IKKβ.
Anti-Flk-1 treatment inhibits growth of s. c. 4T1 and B16 tumors. s. c
Fig. 3 Loss of SBP2 in obesity exacerbated insulin resistance and adipogenesis. Loss of SBP2 in obesity exacerbated insulin resistance and adipogenesis.
Fig. 4 Effects of hematopoietic restoration of TLR9 on adipose tissue inflammation and insulin resistance. Effects of hematopoietic restoration of TLR9.
Dietary coconut oil inhibits GI colonization by C. albicans.
Mean weight change from original weight of (a) BALB/c (b) DBA/2 mice after one (♦) or two (▴) injections of 10 mg/kg and one (▪) or two (×) injections.
Fig. 1 Obesity-related adipocyte degeneration and cfDNA release.
Fig. 5 Effects of in vivo blockade of TLR9 on adipose tissue inflammation and insulin resistance in WT mice. Effects of in vivo blockade of TLR9 on adipose.
Fig. 3. Effects of SFN in mice with diet-induced diabetes.
Presentation transcript:

Cellularity of epididymal adipose tissue. Cellularity of epididymal adipose tissue. Coulter counter measurements of adipocyte size and number in fragments of epididymal adipose tissue from B6 (▪) and AKR (□) mice fed either a standard (A) or high-fat diet (B). The mean adipocyte size in mice fed the standard diet was 63 ± 1 and 70 ± 3 μm (P = 0.05) in the B6 and AKR strain, respectively, whereas adipocyte size in animals fed the high-fat diet was 71 ± 2 and 70 ± 2 μm in B6 and AKR, respectively. Bars are means ± SE (n = 4). *P < 0.05 for B6 vs. AKR fed the same diet. Martin Rossmeisl et al. Diabetes 2003;52:1958-1966 ©2003 by American Diabetes Association