Childhood-to-adolescence evolution of IgE antibodies to pollens and plant foods in the BAMSE cohort Magnus Wickman, MD, PhD, Anna Asarnoj, MD, PhD, Henrike.

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Childhood-to-adolescence evolution of IgE antibodies to pollens and plant foods in the BAMSE cohort Magnus Wickman, MD, PhD, Anna Asarnoj, MD, PhD, Henrike Tillander, Niklas Andersson, MSc, Anna Bergström, PhD, Inger Kull, PhD, Erik Melén, MD, PhD, Göran Pershagen, MD, PhD, Staffan Ahlstedt, PhD, Gunnar Lilja, MD, PhD, Marianne van Hage, MD, PhD Journal of Allergy and Clinical Immunology Volume 133, Issue 2, Pages 580-582.e8 (February 2014) DOI: 10.1016/j.jaci.2013.09.009 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Prevalence of the presence of IgE antibodies (≥0.35 kUA/L) to the 14 airborne and food allergens in Phadiatop and fx5 tested for at age 4, 8, and 16 years among 1699 children in the BAMSE cohort from whom sera were available at all 3 time points. Mold in this context denotes Cladosporium herbarium and mites denote Dermatophagoides pteronyssinus. Journal of Allergy and Clinical Immunology 2014 133, 580-582.e8DOI: (10.1016/j.jaci.2013.09.009) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Prevalence of combined presence of IgE antibodies to birch pollen and peanut (A) and timothy pollen and wheat (B) at age 4, 8, and 16 years among 1699 children in the BAMSE cohort from whom sera were available at all 3 time points. Circles are proportional. Journal of Allergy and Clinical Immunology 2014 133, 580-582.e8DOI: (10.1016/j.jaci.2013.09.009) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Change in the prevalence of, and intrarelationship between, IgE antibodies (≥0.35 kUA/L) to airborne (Phadiatop) and food (fx5) allergens at ages 4, 8, and 16 years among 1699 children in the BAMSE cohort from whom sera were available at all 3 time points. Circles are proportional. Hatched bars denote the prevalence of any allergy-related disease (asthma, rhinitis, or eczema) among sensitized children, and filled bars denote the proportion of children with sensitization, but without any allergy-related disease. All changes in prevalence over time (P < .001). Journal of Allergy and Clinical Immunology 2014 133, 580-582.e8DOI: (10.1016/j.jaci.2013.09.009) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Prevalence and proportional relationship between IgE antibodies (≥0.35 kUA/L) to pollen of birch, timothy, and mugwort at age 4, 8, and 16 years among 1699 children in the BAMSE cohort from whom sera were available at all 3 time points. Journal of Allergy and Clinical Immunology 2014 133, 580-582.e8DOI: (10.1016/j.jaci.2013.09.009) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Prevalence of and proportional relationship between IgE antibodies (≥0.35 kUA/L) to peanut, soy, and wheat at age 4, 8, and 16 years among 1699 children in the BAMSE cohort from whom sera were available at all 3 time points. Journal of Allergy and Clinical Immunology 2014 133, 580-582.e8DOI: (10.1016/j.jaci.2013.09.009) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Median IgE levels and interquartile range (IQR) to birch and timothy pollen in children at age 4, 8, and 16 years. Circles are proportional. For sensitization to birch and timothy pollen, the upper black-hatched circles represent de novo sensitization (number of children sensitized, median IgE, and IQR) between age 4 and 8 years and between age 8 and 16 years. Mid horizontal circles represent children with IgE antibodies at each follow-up (number of sensitized children, median IgE, and IQR). Lower black-hatched circles represent the number of children with transition, that is, the number of children who at the next follow-up exhibited an IgE antibody level of less than 0.35 kU/L to this allergen as well as median IgE and IQR. Journal of Allergy and Clinical Immunology 2014 133, 580-582.e8DOI: (10.1016/j.jaci.2013.09.009) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 Change in median levels and interquartile range (IQR) of IgE antibodies to peanut and wheat in children at age 4, 8, and 16 years. Circles are proportional. For sensitization to peanut and wheat, the upper black-hatched circles represent de novo sensitization (number of children sensitized, median IgE, and IQR) between age 4 and 8 years and between age 8 and 16 years. Mid horizontal circles represent children with IgE antibodies at each follow-up (number of sensitized children, median IgE, and IQR). Lower black-hatched circles represent the number of children with transition, that is, the number of children who at the next follow-up exhibited an IgE antibody level of less than 0.35 kU/L to this allergen as well as median IgE and IQR. Journal of Allergy and Clinical Immunology 2014 133, 580-582.e8DOI: (10.1016/j.jaci.2013.09.009) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions